细胞周期检查点及其在人类癌症中的失活
Cell cycle checkpoints and their inactivation in human cancer.
作者信息
Molinari M
机构信息
European Institute of Oncology, Milan, Italy.
出版信息
Cell Prolif. 2000 Oct;33(5):261-74. doi: 10.1046/j.1365-2184.2000.00191.x.
Abstract
Checkpoints are mechanisms that regulate progression through the cell cycle insuring that each step takes place only once and in the right sequence. Mutations of checkpoint proteins are frequent in all types of cancer as defects in cell cycle control can lead to genetic instability. This review will focus on three major areas of cell cycle transition control, with particular attention to the alterations found in human cancer. These areas include the G1/S transition, where most cancer-related defects occur, the G2/M checkpoint and its activation in response to DNA damage, and the spindle checkpoint.
摘要
关卡是调控细胞周期进程的机制，确保每个步骤仅发生一次且顺序正确。在所有类型的癌症中，关卡蛋白的突变都很常见，因为细胞周期控制缺陷会导致基因不稳定。本综述将聚焦于细胞周期转换控制的三个主要领域，特别关注在人类癌症中发现的改变。这些领域包括G1/S转换（大多数与癌症相关的缺陷发生在此处）、G2/M关卡及其对DNA损伤的激活反应，以及纺锤体关卡。
相似文献
1
Cell cycle checkpoints and their inactivation in human cancer.细胞周期检查点及其在人类癌症中的失活
Cell Prolif. 2000 Oct;33(5):261-74. doi: 10.1046/j.1365-2184.2000.00191.x.
2
Defective cell cycle checkpoint functions in melanoma are associated with altered patterns of gene expression.黑色素瘤中细胞周期检查点功能缺陷与基因表达模式改变有关。
J Invest Dermatol. 2008 Jan;128(1):175-87. doi: 10.1038/sj.jid.5700935. Epub 2007 Jun 28.
3
DNA damage checkpoints: implications for cancer therapy.DNA损伤检查点：对癌症治疗的影响。
Prog Cell Cycle Res. 1996;2:165-73. doi: 10.1007/978-1-4615-5873-6_16.
4
[Cell cycle regulation after exposure to ionizing radiation].[暴露于电离辐射后的细胞周期调控]
Bull Cancer. 1999 Apr;86(4):345-57.
5
Cell cycle checkpoints.细胞周期检查点
Curr Opin Cell Biol. 1994 Dec;6(6):872-6. doi: 10.1016/0955-0674(94)90059-0.
6
p53 does not control the spindle assembly cell cycle checkpoint but mediates G1 arrest in response to disruption of microtubule system.p53并不控制纺锤体组装细胞周期检查点，但能介导G1期阻滞以应对微管系统的破坏。
Cell Biol Int. 1999;23(5):323-34. doi: 10.1006/cbir.1999.0362.
7
Functional analysis of APC-Cdh1.APC-Cdh1的功能分析
Methods Mol Biol. 2004;281:189-98. doi: 10.1385/1-59259-811-0:189.
8
Hypophosphorylation of the RB protein in S and G2 as well as G1 during growth arrest.在生长停滞期间，S期、G2期以及G1期的RB蛋白发生低磷酸化。
Exp Cell Res. 1998 Jun 15;241(2):324-31. doi: 10.1006/excr.1998.4007.
9
S and G2 phase roles for Cdk2 revealed by inducible expression of a dominant-negative mutant in human cells.通过在人类细胞中诱导表达显性负性突变体揭示Cdk2在S期和G2期的作用。
Mol Cell Biol. 2001 Apr;21(8):2755-66. doi: 10.1128/MCB.21.8.2755-2766.2001.
10
Gene expression profiling of HeLa cells in G1 or G2 phases.处于G1期或G2期的HeLa细胞的基因表达谱分析。
Oncogene. 2002 Mar 14;21(12):1934-42. doi: 10.1038/sj.onc.1205264.
引用本文的文献
1
Enhancement of antioxidant and cytotoxicity by nanoliposome formulation of pentagamavunon-6 in breast cancer cells.纳米脂质体包裹的五环伽马弗农-6对乳腺癌细胞抗氧化及细胞毒性的增强作用
Naunyn Schmiedebergs Arch Pharmacol. 2025 Aug 23. doi: 10.1007/s00210-025-04533-w.
2
From survival of irradiated mice to modern molecular insights: a seventy-year journey in radiobiology at the institute of biophysics, Czech academy of sciences.从受辐照小鼠的存活到现代分子见解：捷克科学院生物物理研究所放射生物学的七十年历程
Eur Biophys J. 2025 Jun 13. doi: 10.1007/s00249-025-01765-9.
3
Beyond the Injury: How Does Smoking Impair Stem Cell-Mediated Repair Mechanisms? A Dual Review of Smoking-Induced Stem Cell Damage and Stem Cell-Based Therapeutic Applications.损伤之外：吸烟如何损害干细胞介导的修复机制？吸烟诱导的干细胞损伤与基于干细胞的治疗应用的双重综述
Stem Cell Rev Rep. 2025 Apr 25. doi: 10.1007/s12015-025-10886-9.
4
Small-Molecule Mitotic Inhibitors as Anticancer Agents: Discovery, Classification, Mechanisms of Action, and Clinical Trials.小分子有丝分裂抑制剂作为抗癌药物：发现、分类、作用机制及临床试验
Int J Mol Sci. 2025 Apr 1;26(7):3279. doi: 10.3390/ijms26073279.
5
Functionalized Nanomaterials in Cancer Treatment: A Review.癌症治疗中的功能化纳米材料：综述
Int J Mol Sci. 2025 Mar 14;26(6):2633. doi: 10.3390/ijms26062633.
6
Elucidation of -derived natural compounds in STAT 3 pathway against human cancer cells: and studies.阐明STAT 3信号通路中针对人类癌细胞的源自-的天然化合物：和研究。 （注：原文中“-derived”处有信息缺失，翻译可能不太准确完整）
Front Pharmacol. 2025 Feb 21;16:1507002. doi: 10.3389/fphar.2025.1507002. eCollection 2025.
7
Gintonin-Enriched Extract Induces Apoptosis in Human Melanoma Cells by Causing Cell Cycle Arrest and Activating Caspases.富含人参炔醇的提取物通过导致细胞周期停滞和激活半胱天冬酶诱导人黑色素瘤细胞凋亡。
Foods. 2025 Jan 24;14(3):381. doi: 10.3390/foods14030381.
8
Curcumin-Based Nanoparticles: Advancements and Challenges in Tumor Therapy.基于姜黄素的纳米颗粒：肿瘤治疗的进展与挑战
Pharmaceutics. 2025 Jan 15;17(1):114. doi: 10.3390/pharmaceutics17010114.
9
NKX6.3 modulation of mitotic dynamics and genomic stability in gastric carcinogenesis.NKX6.3对胃癌发生过程中细胞有丝分裂动力学和基因组稳定性的调控
Cell Commun Signal. 2025 Jan 20;23(1):35. doi: 10.1186/s12964-025-02030-4.
10
TH301 Emerges as a Novel Anti-Oncogenic Agent for Human Pancreatic Cancer Cells: The Dispensable Roles of p53, CRY2 and BMAL1 in TH301-Induced /p21 Upregulation.TH301成为一种针对人胰腺癌细胞的新型抗癌剂：p53、CRY2和BMAL1在TH301诱导的p21上调中的非必需作用。
Int J Mol Sci. 2024 Dec 28;26(1):178. doi: 10.3390/ijms26010178.
本文引用的文献
1
DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation.DNA修复蛋白Ku80可抑制染色体畸变和恶性转化。
Nature. 2000 Mar 30;404(6777):510-4. doi: 10.1038/35006670.
2
hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response.hCds1介导的BRCA1磷酸化调控DNA损伤反应。
Nature. 2000 Mar 9;404(6774):201-4. doi: 10.1038/35004614.
3
A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage.一种参与DNA损伤的p53依赖性细胞周期检查点的核糖核苷酸还原酶基因。
Nature. 2000 Mar 2;404(6773):42-9. doi: 10.1038/35003506.
4
Role of the tumor suppressor gene Brca1 in genetic stability and mammary gland tumor formation.肿瘤抑制基因Brca1在遗传稳定性和乳腺肿瘤形成中的作用。
Oncogene. 2000 Feb 21;19(8):1059-64. doi: 10.1038/sj.onc.1203269.
5
DNA damage-induced activation of p53 by the checkpoint kinase Chk2.由关卡激酶Chk2介导的DNA损伤诱导的p53激活。
Science. 2000 Mar 10;287(5459):1824-7. doi: 10.1126/science.287.5459.1824.
6
Requirement of the prolyl isomerase Pin1 for the replication checkpoint.脯氨酰异构酶Pin1对复制检查点的需求。
Science. 2000 Mar 3;287(5458):1644-7. doi: 10.1126/science.287.5458.1644.
7
p53-dependent G2 arrest associated with a decrease in cyclins A2 and B1 levels in a human carcinoma cell line.在一种人类癌细胞系中，p53 依赖性 G2 期阻滞与细胞周期蛋白 A2 和 B1 水平降低相关。
Br J Cancer. 2000 Feb;82(3):642-50. doi: 10.1054/bjoc.1999.0976.
8
The ARF/p53 pathway.ARF/p53 信号通路
Curr Opin Genet Dev. 2000 Feb;10(1):94-9. doi: 10.1016/s0959-437x(99)00038-6.
9
10
Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53.Chk2/hCds1通过稳定p53在G(1)期发挥DNA损伤检查点的作用。
Genes Dev. 2000 Feb 1;14(3):278-88.
Zotero 插件