Fukaya S, Oshima H, Kato K, Komatsu Y, Matsumura H, Ishii K, Miyama H, Nagai T, Tanaka I, Mizutani A, Katayama M, Yoshida S, Torikai K
Department of Medicine, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
Rheumatol Int. 2000;19(6):223-5. doi: 10.1007/s002960000064.
The objective of this study was to determine the role of serum KL-6 levels as a marker for the activity of interstitial pneumonia in patients with connective tissue diseases. The serum concentrations of KL-6, a glycoprotein produced mainly by pulmonary type II epithelial cells, were measured in 21 patients with connective tissue disease. The activity of interstitial pneumonia was compared with the associated serum KL-6 concentrations. Serum KL-6 concentrations in patients with interstitial pneumonia were significantly higher than those in the controls. Among patients with active interstitial pneumonia, serum KL-6 concentrations following the treatment (after improvement) were significantly lower than the pretreatment values. The extent of the pulmonary fibrosis correlated positively with the serum KL-6 concentrations during the inactive phase of the interstitial pneumonia. These results suggest that sequential measurement of serum KL-6 levels is a new and useful means for the evaluation of interstitial pneumonia in patients with connective tissue diseases.
本研究的目的是确定血清KL-6水平作为结缔组织病患者间质性肺炎活动标志物的作用。对21例结缔组织病患者测定了主要由肺II型上皮细胞产生的糖蛋白KL-6的血清浓度。将间质性肺炎的活动情况与相关的血清KL-6浓度进行比较。间质性肺炎患者的血清KL-6浓度显著高于对照组。在活动性间质性肺炎患者中，治疗后（改善后）的血清KL-6浓度显著低于治疗前值。在间质性肺炎非活动期，肺纤维化程度与血清KL-6浓度呈正相关。这些结果表明，连续测定血清KL-6水平是评估结缔组织病患者间质性肺炎的一种新的有用方法。
