Yosipovitch G, Goon A, Wee J, Chan Y H, Goh C L
National Skin Centre, 1 Mandalay Road, Singapore 308205Clinical Trials and Epidemiology Research Unit, National Medical Research Council, Ministry of Health, Singapore.
Br J Dermatol. 2000 Nov;143(5):969-73. doi: 10.1046/j.1365-2133.2000.03829.x.
Many patients with psoriasis are known to suffer from itch. However, the data available regarding itch and its characteristics in psoriasis are sparse.
To examine the prevalence of pruritus and various related clinical characteristics in 101 patients with extensive psoriasis.
A structured questionnaire was used.
Generalized pruritus was a feature of psoriasis in 84% of the patients. In 77% of these it appeared on a daily basis. It involved all areas of the body, had prolonged duration and appeared mainly in the evening and at night. The pruritus significantly affected quality of life. Important daily factors that were found to exacerbate the itch were ambient heat (81%), skin dryness (80%), sweating (65%) and stress (55%). Important factors that were found to ameliorate itch were sleep (57%) and cold showers (55%). The pruritus was found to be unresponsive to most available antipruritics, including phototherapy. Itch intensity as reflected by a visual analogue scale did not correlate with Psoriasis Area and Severity Index scores; however, a highly significant correlation was obtained between the affective descriptors and itch intensity in the worst itch states (r = 0.6, P < 0.001).
Pruritus is a common feature of psoriasis and affects quality of life.
已知许多银屑病患者会出现瘙痒症状。然而，关于银屑病瘙痒及其特征的现有数据较少。
研究101例广泛性银屑病患者中瘙痒症的患病率及各种相关临床特征。
采用结构化问卷。
84%的患者存在全身性瘙痒，其中77%为每日发作。瘙痒累及身体各个部位，持续时间长，主要出现在傍晚和夜间。瘙痒严重影响生活质量。发现加重瘙痒的重要日常因素有环境温度高（81%）、皮肤干燥（80%）、出汗（65%）和压力（55%）。发现减轻瘙痒的重要因素有睡眠（57%）和冷水浴（55%）。发现大多数现有的止痒药，包括光疗，对瘙痒均无反应。视觉模拟量表所反映的瘙痒强度与银屑病面积和严重程度指数评分无关；然而，在最严重的瘙痒状态下，情感描述词与瘙痒强度之间存在高度显著的相关性（r = 0.6，P < 0.001）。
瘙痒是银屑病的常见特征，影响生活质量。
