Ranganath C, Johnson M K, D'Esposito M
Helen Wills Neuroscience Institute and Department of Psychology University of California, Berkeley, California 94720-1650, USA.
J Neurosci. 2000 Nov 15;20(22):RC108. doi: 10.1523/JNEUROSCI.20-22-j0005.2000.
Results from neuroimaging studies have led to competing theories regarding the contributions of prefrontal regions to memory formation and retrieval. To investigate this issue, we used event-related functional magnetic resonance imaging to assess prefrontal activation during encoding and retrieval of pictures of objects. Responses to studied and unstudied objects at retrieval were compared between two tests with differing demands for the specificity of information to be retrieved (source vs old-new recognition). Results showed that bilateral ventral [Brodmann's areas (BA) 44, 45, and 47] and right dorsal (BA 9) prefrontal regions were activated during both encoding and retrieval, but activity in these regions was not reliably modulated by the specificity of information to be retrieved. A region in left anterior prefrontal cortex (BA 10/46) was reliably activated during retrieval trials, and activation in this region increased with demands to retrieve perceptually detailed information about studied objects. Our results show that left anterior prefrontal cortex is engaged during the monitoring and evaluation of specific memory characteristics at retrieval-a process critical for accurate episodic remembering.
神经影像学研究结果引发了关于前额叶区域对记忆形成和提取贡献的相互竞争的理论。为了研究这个问题，我们使用事件相关功能磁共振成像来评估物体图片编码和提取过程中的前额叶激活情况。在两种对要提取信息的特异性有不同要求的测试（来源识别与新旧识别）之间，比较了提取时对已研究和未研究物体的反应。结果显示，双侧腹侧[布罗德曼区（BA）44、45和47]以及右侧背侧（BA 9）前额叶区域在编码和提取过程中均被激活，但这些区域的活动并未因要提取信息的特异性而得到可靠调节。在提取试验期间，左侧前额叶皮层的一个区域（BA 10/46）被可靠激活，并且该区域的激活随着提取有关已研究物体的感知详细信息的要求增加而增强。我们的结果表明，左侧前额叶皮层在提取时对特定记忆特征的监测和评估过程中发挥作用——这一过程对准确的情景记忆至关重要。
