Hemann M T, Greider C W
Predoctoral Training Program in Human Genetics and Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Nucleic Acids Res. 2000 Nov 15;28(22):4474-8. doi: 10.1093/nar/28.22.4474.
Telomere length and telomerase activity directly affect the replicative capacity of primary human cells. Some have suggested that telomere length influences organismal lifespan. We compared telomere length distributions in a number of inbred and outbred established mouse strains with those of strains recently derived from wild mice. Telomere length was considerably shorter in wild-derived strains than in the established strains. We found no correlation of telomere length with lifespan, even among closely related inbred mouse strains. Thus, while telomere length plays a role in cellular lifespan in cultured human cells, it is not a major factor in determining organismal lifespan.
端粒长度和端粒酶活性直接影响原代人类细胞的复制能力。一些人认为端粒长度会影响生物体的寿命。我们比较了许多近交和远交的已建立小鼠品系与最近从野生小鼠衍生而来的品系的端粒长度分布。野生衍生品系的端粒长度比已建立品系的端粒长度短得多。我们发现端粒长度与寿命之间没有相关性，即使在密切相关的近交小鼠品系中也是如此。因此，虽然端粒长度在培养的人类细胞的细胞寿命中起作用，但它不是决定生物体寿命的主要因素。
