Foy T, Marion J, Brigham K L, Harris T R
J Appl Physiol Respir Environ Exerc Physiol. 1979 Jan;46(1):146-51. doi: 10.1152/jappl.1979.46.1.146.
Pseudomonas bacteremia in sheep causes a prolonged increase in lung vascular permeability to protein. Isoproterenol and aminophylline could effect lung fluid balance after Pseudomonas by reducing vascular pressures or by blocking release of permeability mediators. We measured vascular pressures, lung lymph flow, and lymph and plasma protein concentrations in unanesthetized sheep under baseline conditions and during steady-state increased permeability after Pseudomonas. Pseudomonas caused pulmonary vascular pressures to rise and lung lymph flow to increase fivefold, but lymph/plasma protein concentration did not change. Pulmonary vascular pressures and lung lymph flow decreased during intravenous infusion of isoproterenol and aminophylline. The decrease in lymph flow after isoproterenol and isoproterenol plus aminophylline was linearly related to the decrease in microvascular pressure (r = 0.71). Lymph/plasma total protein concentration ratios and lymph clearance of proteins with molecular radii 36--96 A remained high during isoproterenol and aminophylline. These drugs can substantially reduce transvascular filtration primarily because they reduce lung vascular pressures.
绵羊的假单胞菌血症会导致肺血管对蛋白质的通透性长时间增加。异丙肾上腺素和氨茶碱可通过降低血管压力或阻断通透性介质的释放来影响假单胞菌感染后的肺液体平衡。我们在未麻醉的绵羊处于基线状态以及假单胞菌感染后稳态通透性增加期间，测量了血管压力、肺淋巴流量以及淋巴和血浆蛋白浓度。假单胞菌导致肺血管压力升高，肺淋巴流量增加五倍，但淋巴/血浆蛋白浓度未改变。在静脉输注异丙肾上腺素和氨茶碱期间，肺血管压力和肺淋巴流量降低。异丙肾上腺素以及异丙肾上腺素加氨茶碱后淋巴流量的降低与微血管压力的降低呈线性相关（r = 0.71）。在使用异丙肾上腺素和氨茶碱期间，淋巴/血浆总蛋白浓度比值以及分子半径为36 - 96 Å的蛋白质的淋巴清除率仍然很高。这些药物可大幅减少跨血管滤过，主要是因为它们降低了肺血管压力。
