独特的假尾孢菌素代谢产物提示了一个涉及 Diels-Alder 反应和随后的机制多样化的生物合成假说。
Unique metabolites of Pestalotiopsis fici suggest a biosynthetic hypothesis involving a Diels-Alder reaction and then mechanistic diversification.
机构信息
Key Laboratory of Systematic Mycology & Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, People's Republic of China.
出版信息
Chem Commun (Camb). 2010 Jan 21;46(3):460-2. doi: 10.1039/b918330b. Epub 2009 Nov 13.
DOI:10.1039/b918330b
PMID:20066325
Abstract
Chloropupukeanolides A (1) and B (2), unprecedented spiroketal peroxides, and chloropupukeanone A (3), three highly functionalized metabolites featuring a chlorinated pupukeanane core, were isolated from an endophytic fungus Pestalotiopsis fici, with 1 showing significant anti-HIV-1 and cytotoxic effects.
摘要
氯蒲桃叶烷酮 A（1）和 B（2），前所未有的螺环过氧化物，以及氯蒲桃酮 A（3），这三种具有高度官能化代谢产物均具有氯化蒲桃烷核心，是从内生真菌 Pestalotiopsis fici 中分离得到的，其中 1 具有显著的抗 HIV-1 和细胞毒性作用。
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