组氨酸操纵子的调控不需要hisG酶。
Regulation of histidine operon does not require hisG enzyme.
作者信息
Scott J F, Roth J R, Artz S W
出版信息
Proc Natl Acad Sci U S A. 1975 Dec;72(12):5021-5. doi: 10.1073/pnas.72.12.5021.
Abstract
Mutations are described which delete all or part of the first structural gene (hisG) of the histidine operon of Salmonella typhimurium. Physiological regulation of histidine enzymes occurs normally in strains carrying any deletion that has both endpoints within the hisG gene. Constitutive high operon expression is observed in strains carrying any hisG deletion and an unlinked regulatory mutation, hisT1504. These results strongly indicate that the hisG protein is not an essential component of the mechanism for regulating expression of the histidine operon.
摘要
已描述了一些突变，这些突变会删除鼠伤寒沙门氏菌组氨酸操纵子的第一个结构基因（hisG）的全部或部分。在携带任何两个端点都在hisG基因内的缺失的菌株中，组氨酸酶的生理调节正常发生。在携带任何hisG缺失和一个不连锁的调节突变hisT1504的菌株中观察到组成型高操纵子表达。这些结果有力地表明，hisG蛋白不是调节组氨酸操纵子表达机制的必需成分。
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Proc Natl Acad Sci U S A. 1975 Dec;72(12):5021-5. doi: 10.1073/pnas.72.12.5021.
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