The effects of n-dipropylacetate on the acquisition of conditioned behaviour with negative reinforcement in mice.

n-Dipropylacetate (nDPA), at a dose of 100 mg/kg, has a facilitating action on the acquisition of conditioned reactions with negative reinforcement in mice. On the other hand, nDPA reduces the number of conditioned reactions with a dose of 200 mg/kg. These effects of nDPA on conditioned behaviour are correlated with the increase of the level of brain gamma-aminobutyric acid, following administration of nDPA.