Kalinka J, Hanke W, Sobala W, Suzin J
Kliniki Perinatologii, Instytutu Ginekologii i Połoznictwa AM w Lodzi.
Ginekol Pol. 2000 Aug;71(8):653-7.
Influence of environmental smoke exposure during pregnancy on umbilical blood flow velocity and newborns birthweight was assessed in prospective study among 116 pregnant women between 20 and 24 week of pregnancy. The main aim was to search for a possible correlation between cotinine, an effective marker of smoke exposure, and umbilical blood flow as measured by S/D, RI and PI ratios. This study shows a significant increase of systolic/diastolic velocity ratio of the umbilical artery according with increased cotinine levels, either for active or passive smokers. Increase of S/D ratio > 3.0 in umbilical artery in 20-24 week of pregnancy was negatively correlated with newborns birthweight. The results of this study suggest that active and passive smoking by pregnant women causes a direct increase in the vascular resistance of the placenta and contribute to the decreased of the newborns birthweight associated with smoking.
在一项针对116名怀孕20至24周孕妇的前瞻性研究中，评估了孕期环境烟雾暴露对脐血流速度和新生儿出生体重的影响。主要目的是寻找可替宁（一种烟雾暴露的有效标志物）与通过S/D、RI和PI比值测量的脐血流之间可能存在的相关性。该研究表明，无论是主动吸烟者还是被动吸烟者，随着可替宁水平的升高，脐动脉收缩/舒张速度比值显著增加。妊娠20至24周时脐动脉S/D比值>3.0的增加与新生儿出生体重呈负相关。这项研究的结果表明，孕妇主动和被动吸烟会直接导致胎盘血管阻力增加，并导致与吸烟相关的新生儿出生体重下降。
