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1
Antiretroviral agents inhibit infection of human cells by porcine endogenous retroviruses.抗逆转录病毒药物可抑制猪内源性逆转录病毒对人类细胞的感染。
Antimicrob Agents Chemother. 2000 Dec;44(12):3432-3. doi: 10.1128/AAC.44.12.3432-3433.2000.
2
Susceptibility of the porcine endogenous retrovirus to reverse transcriptase and protease inhibitors.猪内源性逆转录病毒对逆转录酶和蛋白酶抑制剂的敏感性。
J Virol. 2001 Jan;75(2):1048-53. doi: 10.1128/JVI.75.2.1048-1053.2001.
3
Use of recombinant retroviruses to characterize the activity of antiretroviral compounds.利用重组逆转录病毒来表征抗逆转录病毒化合物的活性。
J Virol. 1991 Nov;65(11):6339-42. doi: 10.1128/JVI.65.11.6339-6342.1991.
4
Inhibition of human immunodeficiency virus type 1 replication in vitro by the bisheteroarylpiperazine atevirdine (U-87201E) in combination with zidovudine or didanosine.
J Infect Dis. 1993 Aug;168(2):318-26. doi: 10.1093/infdis/168.2.318.
5
Differential susceptibility of retroviruses to nucleoside analogues.逆转录病毒对核苷类似物的敏感性差异。
Antivir Chem Chemother. 2001 Mar;12(2):91-7. doi: 10.1177/095632020101200202.
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Efficacy of antiretroviral agents against murine replication-competent retrovirus infection in human cells.抗逆转录病毒药物对人类细胞中具有复制能力的鼠逆转录病毒感染的疗效。
J Virol. 1999 Oct;73(10):8813-6. doi: 10.1128/JVI.73.10.8813-8816.1999.
7
Porcine endogenous retroviruses (PERVs): generation of specific antibodies, development of an immunoperoxidase assay (IPA) and inhibition by AZT.猪内源性逆转录病毒（PERVs）：特异性抗体的产生、免疫过氧化物酶测定法（IPA）的开发以及齐多夫定的抑制作用
Xenotransplantation. 2001 Nov;8(4):310-6. doi: 10.1034/j.1399-3089.2001.00098.x.
8
Characterization of chromosomally assigned replication-competent gamma porcine endogenous retroviruses derived from a large white pig and expression in human cells.源自大白猪的染色体定位的具有复制能力的γ型猪内源性逆转录病毒的特性及其在人细胞中的表达
J Virol. 2002 Mar;76(6):2714-20. doi: 10.1128/jvi.76.6.2714-2720.2002.
9
The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes--chapter 5: Strategies to prevent transmission of porcine endogenous retroviruses.国际异种移植协会关于开展1型糖尿病猪胰岛产品临床试验条件的共识声明——第5章：预防猪内源性逆转录病毒传播的策略
Xenotransplantation. 2009 Jul-Aug;16(4):239-48. doi: 10.1111/j.1399-3089.2009.00544.x.
10
Altered drug sensitivity, fitness, and evolution of human immunodeficiency virus type 1 with pol gene mutations conferring multi-dideoxynucleoside resistance.具有赋予多双脱氧核苷抗性的 pol 基因突变的 1 型人类免疫缺陷病毒的药物敏感性改变、适应性及进化。
J Infect Dis. 1998 May;177(5):1207-13. doi: 10.1086/515282.

引用本文的文献

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Surveillance and prevention of infection in clinical xenotransplantation.临床异种移植中感染的监测与预防
Clin Microbiol Rev. 2025 Mar 13;38(1):e0015023. doi: 10.1128/cmr.00150-23. Epub 2025 Jan 31.
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Virus Safety of Xenotransplantation.异种移植的病毒安全性。
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Porcine Endogenous Retroviruses and Xenotransplantation, 2021.猪内源性逆转录病毒与异种移植，2021 年。
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Do Antiretroviral Drugs Protect From Multiple Sclerosis by Inhibiting Expression of MS-Associated Retrovirus?抗逆转录病毒药物是否通过抑制与多发性硬化症相关的逆转录病毒的表达来保护机体免受多发性硬化症的侵害？
Front Immunol. 2019 Jan 22;9:3092. doi: 10.3389/fimmu.2018.03092. eCollection 2018.
7
Can Antiretroviral Drugs Be Used to Treat Porcine Endogenous Retrovirus (PERV) Infection after Xenotransplantation?抗逆转录病毒药物能否用于治疗异种移植后的猪内源性逆转录病毒（PERV）感染？
Viruses. 2017 Aug 8;9(8):213. doi: 10.3390/v9080213.
8
Susceptibility of porcine endogenous retrovirus to anti-retroviral inhibitors.猪内源性逆转录病毒对抗逆转录病毒抑制剂的敏感性。
Xenotransplantation. 2016 Mar;23(2):151-8. doi: 10.1111/xen.12230. Epub 2016 Mar 29.
9
Infection barriers to successful xenotransplantation focusing on porcine endogenous retroviruses.针对猪内源性逆转录病毒的成功异种移植的感染屏障。
Clin Microbiol Rev. 2012 Apr;25(2):318-43. doi: 10.1128/CMR.05011-11.
10
Restriction of porcine endogenous retrovirus by porcine APOBEC3 cytidine deaminases.猪 APOBEC3 胞嘧啶脱氨酶对猪内源性逆转录病毒的限制作用。
J Virol. 2011 Apr;85(8):3842-57. doi: 10.1128/JVI.01880-10. Epub 2011 Feb 9.

本文引用的文献

1
Efficacy of antiretroviral agents against murine replication-competent retrovirus infection in human cells.抗逆转录病毒药物对人类细胞中具有复制能力的鼠逆转录病毒感染的疗效。
J Virol. 1999 Oct;73(10):8813-6. doi: 10.1128/JVI.73.10.8813-8816.1999.
2
Search for cross-species transmission of porcine endogenous retrovirus in patients treated with living pig tissue. The XEN 111 Study Group.在接受猪活体组织治疗的患者中寻找猪内源性逆转录病毒的跨物种传播。XEN 111研究小组。
Science. 1999 Aug 20;285(5431):1236-41. doi: 10.1126/science.285.5431.1236.
3
Host range and interference studies of three classes of pig endogenous retrovirus.三类猪内源性逆转录病毒的宿主范围及干扰研究
J Virol. 1998 Dec;72(12):9986-91. doi: 10.1128/JVI.72.12.9986-9991.1998.
4
No evidence of pig DNA or retroviral infection in patients with short-term extracorporeal connection to pig kidneys.短期进行猪肾体外连接的患者中未发现猪DNA或逆转录病毒感染的证据。
Lancet. 1998 Aug 29;352(9129):699-701. doi: 10.1016/S0140-6736(98)04369-4.
5
No evidence of infection with porcine endogenous retrovirus in recipients of porcine islet-cell xenografts.在猪胰岛细胞异种移植受者中未发现感染猪内源性逆转录病毒的证据。
Lancet. 1998 Aug 29;352(9129):695-9. doi: 10.1016/S0140-6736(98)07145-1.
6
Porcine endogenous retrovirus (PERV) was not transmitted from transplanted porcine endothelial cells to baboons in vivo.猪内源性逆转录病毒（PERV）在体内未从移植的猪内皮细胞传播至狒狒。
Transpl Int. 1998;11(4):247-51. doi: 10.1007/s001470050136.
7
Type C retrovirus released from porcine primary peripheral blood mononuclear cells infects human cells.从猪原代外周血单个核细胞释放的C型逆转录病毒感染人类细胞。
J Virol. 1998 Apr;72(4):3082-7. doi: 10.1128/JVI.72.4.3082-3087.1998.
8
Infection of human cells by an endogenous retrovirus of pigs.猪内源性逆转录病毒对人类细胞的感染。
Nat Med. 1997 Mar;3(3):282-6. doi: 10.1038/nm0397-282.
9
Stavudine: a review of its pharmacodynamic and pharmacokinetic properties and clinical potential in HIV infection.
Drugs. 1996 May;51(5):846-64. doi: 10.2165/00003495-199651050-00009.
10
Evaluation of reverse transcriptase and protease inhibitors in two-drug combinations against human immunodeficiency virus replication.评估逆转录酶抑制剂和蛋白酶抑制剂两药联合使用对人类免疫缺陷病毒复制的作用。
Antimicrob Agents Chemother. 1996 Jun;40(6):1346-51. doi: 10.1128/AAC.40.6.1346.

抗逆转录病毒药物可抑制猪内源性逆转录病毒对人类细胞的感染。

Antiretroviral agents inhibit infection of human cells by porcine endogenous retroviruses.

作者信息

Powell S K, Gates M E, Langford G, Gu M L, Lockey C, Long Z, Otto E

机构信息

Genetic Therapy, Inc., a Novartis Company, Gaithersburg, Maryland 20878, USA.

出版信息

Antimicrob Agents Chemother. 2000 Dec;44(12):3432-3. doi: 10.1128/AAC.44.12.3432-3433.2000.

DOI:10.1128/AAC.44.12.3432-3433.2000
PMID:11083652
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC90217/
Abstract

The efficacy of antiretroviral drugs against porcine endogenous retroviruses (PERV) that may be harbored in pig organs intended for transplantation was examined in human cells in vitro. The nucleoside analogs zidovudine and dideoxyinosine were found to effectively inhibit PERV replication.

摘要

在体外培养的人体细胞中检测了抗逆转录病毒药物对猪器官中可能携带的猪内源性逆转录病毒（PERV）的疗效。发现核苷类似物齐多夫定和双脱氧肌苷能有效抑制PERV复制。