Ferry B, Di Scala G
UMR 7521, Centre National de la Recherche Scientifique, Université Louis Pasteur, Strasbourg, France.
Behav Neurosci. 2000 Oct;114(5):1005-10.
In the taste-potentiated odor aversion (TPOA) paradigm, animals acquire a strong aversion to an odor that is followed by delayed intoxication only if a gustatory stimulus is presented with the odor during conditioning. Although previous work has shown that N-methyl-D-aspartate (NMDA) receptors in the basolateral nucleus of the amygdala (BLA) play a role in the acquisition of TPOA, the present study aimed at describing the process in which NMDA receptors in the BLA are involved during acquisition of TPOA. Male Long-Evans rats received intra-BLA infusions of the competitive NMDA receptor antagonist D,L-2-2-amino-5-phosphonovalerate (D-APV; 0.05 and 0.50 microg) immediately before or after the odor-taste conditioned stimulus (CS) presentation, or immediately before the test. Results showed that D-APV impaired acquisition of TPOA when infused before, but not after, the CS presentation, but did not affect retrieval. These results suggest that NMDA receptors of the BLA are involved in the formation of potentiation--by taste--of the olfactory memory trace, but not in the maintenance of this process.
在味觉增强气味厌恶（TPOA）范式中，只有在条件反射过程中味觉刺激与气味同时呈现时，动物才会对随后出现延迟中毒反应的气味产生强烈厌恶。尽管先前的研究表明，杏仁核基底外侧核（BLA）中的N-甲基-D-天冬氨酸（NMDA）受体在TPOA的形成中起作用，但本研究旨在描述在TPOA形成过程中BLA中的NMDA受体所涉及的过程。雄性Long-Evans大鼠在气味-味觉条件刺激（CS）呈现之前或之后，或在测试之前立即接受BLA内竞争性NMDA受体拮抗剂D，L-2-氨基-5-磷酸戊酸（D-APV；0.05和0.50微克）的注射。结果表明，在CS呈现之前而非之后注射D-APV会损害TPOA的形成，但不影响记忆提取。这些结果表明，BLA的NMDA受体参与了嗅觉记忆痕迹通过味觉增强的形成过程，但不参与该过程的维持。
