2-烷基（烷硫基）-5-吡唑基-1,3,4-恶二唑（噻二唑）对茄丝核菌的合成及杀菌活性

Synthesis and fungicidal activity against Rhizoctonia solani of 2-alkyl (Alkylthio)-5-pyrazolyl-1,3,4-oxadiazoles (Thiadiazoles).

作者信息

Chen H, Li Z, Han Y

机构信息

State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, People's Republic of China.

出版信息

J Agric Food Chem. 2000 Nov;48(11):5312-5. doi: 10.1021/jf991065s.

DOI:10.1021/jf991065s

PMID:11087478

Abstract

Some series of 2-alkyl (alkythio)-5-((4-chloro)-3-ethyl-1-methyl-1H-pyrazole-5-yl)-1,3, 4-oxadiazoles (thiadiazoles) were prepared as potential fungicides. Their fungicidal activity was evaluated against rice sheath blight, which is a major disease of rice in China. Structure-activity relationships for the screened compounds were evaluated and discussed. It was found that 5-(4-chloro-3-ethyl-1-methyl-1H-pyrazole-5-yl)-1,3, 4-thiadiazole-2-thione has the higher fungicidal activity.

摘要

制备了一些系列的2-烷基（烷硫基）-5-（（4-氯）-3-乙基-1-甲基-1H-吡唑-5-基）-1,3,4-恶二唑（噻二唑）作为潜在的杀菌剂。针对水稻纹枯病（中国水稻的一种主要病害）评估了它们的杀菌活性。对筛选出的化合物的构效关系进行了评估和讨论。发现5-（4-氯-3-乙基-1-甲基-1H-吡唑-5-基）-1,3,4-噻二唑-2-硫酮具有较高的杀菌活性。