大鼠口服给药后绿原酸和咖啡酸的吸收情况。

Absorption of chlorogenic acid and caffeic acid in rats after oral administration.

作者信息

Azuma K, Ippoushi K, Nakayama M, Ito H, Higashio H, Terao J

机构信息

National Research Institute of Vegetables, Ornamental Plants and Tea, Ano, Mie 514-2392, Japan.

出版信息

J Agric Food Chem. 2000 Nov;48(11):5496-500. doi: 10.1021/jf000483q.

DOI:10.1021/jf000483q

PMID:11087508

Abstract

Absorption of orally administered chlorogenic acid (5-caffeoylquinic acid) and caffeic acid in rats was studied to obtain plasma pharmacokinetic profiles of their metabolites. Rats were administered 700 micromol/kg body weight of chlorogenic or caffeic acid, and blood was collected from the tail for 6 h after administration. Ingested caffeic acid was absorbed from the alimentary tract and was present in the rat blood circulation in the form of various metabolites. On the other hand, only traces of metabolites, supposedly caffeic and ferulic acids conjugates, were detected in rat plasma for 6 h after chlorogenic acid administration. Chlorogenic acid and small amounts of caffeic acid were found in the small intestine for 6 h after chlorogenic acid administration. These results suggest that chlorogenic acid is not well absorbed from the digestive tract, unlike caffeic acid, and subject to almost no structural changes to the easily absorbed forms.

摘要

研究了大鼠口服绿原酸（5-咖啡酰奎尼酸）和咖啡酸的吸收情况，以获得它们代谢产物的血浆药代动力学曲线。给大鼠按700微摩尔/千克体重的剂量灌胃绿原酸或咖啡酸，并在给药后6小时从大鼠尾部采血。摄入的咖啡酸从消化道吸收，并以各种代谢产物的形式存在于大鼠血液循环中。另一方面，在给予绿原酸后6小时内，仅在大鼠血浆中检测到痕量的代谢产物，推测为咖啡酸和阿魏酸的共轭物。给予绿原酸后6小时，在小肠中发现了绿原酸和少量咖啡酸。这些结果表明，与咖啡酸不同，绿原酸在消化道中吸收不佳，且几乎不会发生结构变化形成易于吸收的形式。