Jozsi A C, Dupont-Versteegden E E, Taylor-Jones J M, Evans W J, Trappe T A, Campbell W W, Peterson C A
Reynolds Department of Geriatrics and Center on Aging, University of Arkansas for Medical Sciences, 629 South Elm Street, Little Rock, AR 72205, USA.
Mech Ageing Dev. 2000 Dec 1;120(1-3):45-56. doi: 10.1016/s0047-6374(00)00178-0.
The gene expression profile of skeletal muscle from healthy older (62-75 years old) compared with younger (20-34 years old) men demonstrated elevated expression of genes typical of a stress or damage response, and decreased expression of a gene encoding a DNA repair/cell cycle checkpoint protein. Although the expression of these genes was relatively unaffected by a single bout of resistance exercise in older men, acute exercise altered gene expression in younger men such that post-exercise gene expression in younger men was similar to baseline gene expression in older men. The lack of response of muscle from older subjects to resistance exercise was also apparent in the expression of the inflammatory response gene IL-1beta, which did not differ between the age groups at baseline, but increased within 24 h of the exercise bout only in younger subjects. Other genes with potentially important roles in the adaptation of muscle to exercise, specifically in the processes of angiogenesis and cell proliferation, showed a similar response to exercise in older compared with younger subjects. Only one gene encoding the multifunctional, early growth response transcription factor EGR-1, showed an opposite pattern of expression in response to exercise, acutely decreasing in younger and increasing in older subjects. These results may provide a molecular basis for the inherent variability in the response of muscle from older as compared with younger individuals to resistance training.
与年轻男性（20 - 34岁）相比，健康老年男性（62 - 75岁）骨骼肌的基因表达谱显示，应激或损伤反应相关典型基因的表达升高，而编码DNA修复/细胞周期检查点蛋白的基因表达降低。尽管这些基因的表达在老年男性单次抗阻运动后相对未受影响，但急性运动改变了年轻男性的基因表达，使得年轻男性运动后的基因表达与老年男性的基线基因表达相似。炎症反应基因IL - 1β的表达也表明老年受试者的肌肉对抗阻运动缺乏反应，该基因在基线时年龄组间无差异，但仅在年轻受试者运动后24小时内升高。其他在肌肉适应运动中具有潜在重要作用的基因，特别是在血管生成和细胞增殖过程中，老年受试者与年轻受试者对运动的反应相似。只有一个编码多功能早期生长反应转录因子EGR - 1的基因，在运动反应中表现出相反的表达模式，在年轻受试者中急性降低，而在老年受试者中升高。这些结果可能为老年个体与年轻个体相比，肌肉对阻力训练反应的内在变异性提供分子基础。
