运动诱导的 MYC 作为一种对抗骨骼肌衰老的表观遗传重编程因子。
Exercise-Induced MYC as an Epigenetic Reprogramming Factor That Combats Skeletal Muscle Aging.
机构信息
Exercise Science Research Center, Molecular Muscle Mass Regulation Laboratory, Department of Health, Human Performance, and Recreation, University of Arkansas, Fayetteville, AR.
Neuropediatrics, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
出版信息
Exerc Sport Sci Rev. 2024 Apr 1;52(2):63-67. doi: 10.1249/JES.0000000000000333. Epub 2024 Feb 23.
Of the "Yamanaka factors" Oct3/4 , Sox2 , Klf4 , and c-Myc (OSKM), the transcription factor c-Myc ( Myc ) is the most responsive to exercise in skeletal muscle and is enriched within the muscle fiber. We hypothesize that the pulsatile induction of MYC protein after bouts of exercise can serve to epigenetically reprogram skeletal muscle toward a more resilient and functional state.
在“山中因子”Oct3/4、Sox2、Klf4 和 c-Myc（OSKM）中，转录因子 c-Myc（Myc）对骨骼肌中的运动反应最敏感，并且富集在肌纤维内。我们假设运动后的 MYC 蛋白的脉冲诱导可以使骨骼肌在表观遗传层面上向更具弹性和功能性的状态重新编程。
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