Pan Z, Mølhave L, Kjaergaard S K
Department of Environmental and Occupational Medicine, University of Aarhus, Denmark.
Indoor Air. 2000 Dec;10(4):237-45. doi: 10.1034/j.1600-0668.2000.010004237.x.
To test sensory irritation symptoms and physiological effects on humans caused by airborne office dust, ten subjects were exposed to both clean air and airborne non-industrial office dust for 3 h in a climate chamber. The average dust concentration in exposure sessions was 394 micrograms/m3 total suspended dust (TSD). Tear film break-up time, foam formation in the eye canthus, conjunctival epithelial damage, nasal volume, and nasal minimal cross-sectional area were assessed. Tear film break-up time decreased significantly after dust exposure and nasal volume showed a tendency to decrease. In a questionnaire investigation, significant effects were found from the questions: "facial skin humidity", "throat irritation", "feeling needs of coughing", "dry nose", "concentration difficulty", and "headache". Additionally, the intensity of the questions "facial skin humidity", "dry nose", "body skin temperature", "sluggishness", and "sleepiness" worsened over time. A correlation analysis showed that perceived "air quality" was significantly correlated with "dry eyes", "eye irritation", "facial skin irritation", "nose irritation", and "feeling stressed by chamber occupancy" for subacute responses, and with "odor intensity" for acute responses. This supports that the perceived air quality may be a function of odor and irritation symptoms. A number of localized symptoms of irritation (e.g. dry nose, throat irritation, coughing) and of general symptoms (e.g. sluggishness, sleepiness, headache, ability to concentration) were mutually correlated acutely and subacutely. These results indicate that non-industrial office dust may cause physiological changes and sensory symptoms in eyes and nose and that these effects have different time courses.
为测试空气中的办公灰尘对人体造成的感觉刺激症状和生理影响，10名受试者在气候舱中分别暴露于清洁空气和空气中的非工业办公灰尘中3小时。暴露期间的平均灰尘浓度为总悬浮灰尘（TSD）394微克/立方米。评估了泪膜破裂时间、眼角泡沫形成、结膜上皮损伤、鼻腔容积和鼻腔最小横截面积。灰尘暴露后泪膜破裂时间显著缩短，鼻腔容积有减小趋势。在问卷调查中，发现“面部皮肤湿度”“喉咙刺激”“咳嗽感觉需求”“鼻子干燥”“注意力不集中”和“头痛”等问题有显著影响。此外，“面部皮肤湿度”“鼻子干燥”“身体皮肤温度”“倦怠”和“嗜睡”等问题的强度随时间恶化。相关性分析表明，对于亚急性反应，感知到的“空气质量”与“干眼”“眼睛刺激”“面部皮肤刺激”“鼻子刺激”和“因舱内环境感到压力”显著相关，对于急性反应，与“气味强度”显著相关。这支持了感知到的空气质量可能是气味和刺激症状的函数。许多局部刺激症状（如鼻子干燥、喉咙刺激、咳嗽）和一般症状（如倦怠、嗜睡、头痛、注意力集中能力）在急性和亚急性情况下相互关联。这些结果表明，非工业办公灰尘可能会引起眼睛和鼻子的生理变化和感觉症状，且这些影响具有不同的时间进程。
