黄柏与五加皮1:1混合物的水提取物对糖尿病大鼠肾脏的氧化应激具有抑制作用。
Water extract of 1:1 mixture of Phellodendron cortex and Aralia cortex has inhibitory effects on oxidative stress in kidney of diabetic rats.
作者信息
Lee Y M, Kim H, Hong E K, Kang B H, Kim S J
机构信息
Department of Food and Nutrition, College of Human Ecology, Seoul National University, 151-742, Seoul, South Korea.
出版信息
J Ethnopharmacol. 2000 Dec;73(3):429-36. doi: 10.1016/s0378-8741(00)00302-0.
Enhanced activity of the lipid peroxidation and oxidative damages have been implicated in the pathogenesis of diabetic kidney complications. We explored to determine whether these changes in diabetic kidney could be prevented by water extract of mixture of Phellodendron cortex and Aralia cortex (P55A). Greatly elevated content of thiobarbituric acid reactive substances (TBARS) and carbonylated protein in kidneys of diabetic rats were significantly reduced by P55A treatment. In addition, abnormally low ratio of GSH/GSSG in diabetic kidneys was elevated to almost normal levels by the treatment with P55A. These results suggest that P55A extracts exert antioxidant effect by reducing lipid peroxidation and protein carbonylation as well as by elevating the ratio of GSF/GSSG in diabetic kidney.
脂质过氧化增强及氧化损伤与糖尿病肾脏并发症的发病机制有关。我们进行研究以确定黄柏皮与五加皮混合物的水提取物（P55A）是否可以预防糖尿病肾脏的这些变化。P55A处理可显著降低糖尿病大鼠肾脏中硫代巴比妥酸反应性物质（TBARS）和羰基化蛋白的含量，而这两者在糖尿病大鼠肾脏中的含量大幅升高。此外，P55A处理可使糖尿病肾脏中异常低的谷胱甘肽/氧化型谷胱甘肽（GSH/GSSG）比值升高至几乎正常水平。这些结果表明，P55A提取物可通过减少脂质过氧化和蛋白质羰基化以及提高糖尿病肾脏中GSF/GSSG比值来发挥抗氧化作用。
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