Aldebasi Yousef H, Aly Salah M, Rahmani Arshad H
Department of Optometry, College of Applied Medical Sciences, Qassim University Saudi Arabia.
Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University Saudi Arabia ; Department of Pathology, Faculty of Vet. Medicine, Suez Canal University Ismailia, Egypt.
Int J Physiol Pathophysiol Pharmacol. 2013 Dec 15;5(4):194-202.
Diabetic Retinopathy (DR) is one of the most common complications of diabetes mellitus that affects the blood vessels of the retina, leading to blindness. The current approach of treatment based on anti-inflammatory, anti-angiogenesis drugs and laser photocoagulation are effective but also shows adverse affect in retinal tissues and that can even worsen the visual abilities. Thus, a safe and effective mode of treatment is needed to control or delaying the DR. Based on the earlier evidence of the potentiality of natural products as anti-oxidants, anti-diabetic and antitumor, medicinal plants may constitute a good therapeutic approach in the prevention of DR. Curcumin, constituents of dietary spice turmeric, has been observed to have therapeutic potential in the inhibition or slow down progression of DR. In this review, we summarize the therapeutic potentiality of curcumin in the delaying the DR through antioxidant, anti-inflammatory, inhibition of Vascular Endothelial Growth and nuclear transcription factors. The strength of involvement of curcumin in the modulation of genes action creates a strong optimism towards novel therapeutic strategy of diabetic retinopathy and important mainstay in the management of diabetes and its complications DR.
糖尿病视网膜病变（DR）是糖尿病最常见的并发症之一，它会影响视网膜血管，导致失明。目前基于抗炎、抗血管生成药物和激光光凝的治疗方法虽有效果，但也会对视网膜组织产生不良影响，甚至会使视力恶化。因此，需要一种安全有效的治疗方式来控制或延缓糖尿病视网膜病变。基于天然产物具有抗氧化、抗糖尿病和抗肿瘤潜力的早期证据，药用植物可能构成预防糖尿病视网膜病变的良好治疗方法。姜黄素是膳食香料姜黄的成分，已观察到其在抑制或减缓糖尿病视网膜病变进展方面具有治疗潜力。在本综述中，我们总结了姜黄素通过抗氧化、抗炎、抑制血管内皮生长和核转录因子来延缓糖尿病视网膜病变的治疗潜力。姜黄素参与基因作用调节的强度为糖尿病视网膜病变的新型治疗策略带来了强烈的乐观情绪，并且是糖尿病及其并发症糖尿病视网膜病变管理中的重要支柱。
