手术对肿瘤导向性白细胞反应的影响。
Effect of surgery on tumour-directed leucocyte responses.
作者信息
Vose B M, Moudgil G C
出版信息
Br Med J. 1975 Jan 11;1(5949):56-8. doi: 10.1136/bmj.1.5949.56.
Abstract
Leucocytes from 22 out of 26 patients with mammary carcinoma were significantly cytotoxic in vitro for cells cultured from mammary tumours though only two out of 17 of these preparations were cytotoxic for cells cultured from tumours arising at other sites. In the immediate postoperative period reactivity of patients' leucocytes with mammary tumour cells was undetectable but returned within one week of surgery. Leucocyte cytotoxicity may therefore offer a model in which the mechanism of postoperative depression of immunological competence may be investigated.
摘要
26例乳腺癌患者中有22例患者的白细胞在体外对乳腺肿瘤培养细胞具有显著的细胞毒性，尽管这些样本中只有2份对其他部位肿瘤培养细胞具有细胞毒性。在术后即刻，未检测到患者白细胞与乳腺肿瘤细胞的反应性，但在术后一周内恢复。因此，白细胞细胞毒性可能提供了一个模型，用以研究术后免疫能力下降的机制。
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