Vose B M, Moudgil G C
Immunology. 1976 Jan;30(1):123-8.
Leucocytes taken 1 day post-operatively from patients who had undergone surgery under general anaesthesia for benign breast disease showed a significantly diminished capacity to induce lysis of antibody-coated target cells compared with those taken pre-operatively from the same patients. No significant fall in PHA responsiveness was observed in these leucocytes in the post-operative period. This indicates a high sensitivity of the cell types involved in the antibody-dependent cell-mediated cytotoxicity reaction to the suppressive effect of surgery and anaesthesia. Plasmas taken post-operatively from these patients were effective in diminishing the capacity of leucocytes from healthy untreated donors to initiate antibody-coated target cell lysis compared with pre-operative plasmas although the plasma cortisol levels in these samples did not differ significantly. Possible mediators of this suppressive effect and its significance are discussed.
与同一患者术前采集的白细胞相比，接受全身麻醉下良性乳腺疾病手术的患者术后1天采集的白细胞诱导抗体包被靶细胞裂解的能力显著降低。在术后期间，这些白细胞的PHA反应性未观察到显著下降。这表明参与抗体依赖性细胞介导的细胞毒性反应的细胞类型对手术和麻醉的抑制作用高度敏感。与术前血浆相比，这些患者术后采集的血浆在降低未治疗的健康供体白细胞引发抗体包被靶细胞裂解的能力方面有效，尽管这些样本中的血浆皮质醇水平没有显著差异。讨论了这种抑制作用的可能介质及其意义。
