Müller T, Schäfer S, Kuhn W, Przuntek H
Department of Neurology, St Josef Hospital, Ruhr University Bochum, Germany.
Can J Neurol Sci. 2000 Nov;27(4):311-5. doi: 10.1017/s0317167100001062.
Various investigators have developed complex quantitative instrumental procedures for objective assessment of parkinsonian motor impairment, since drawbacks of rating scales are interrater variability, subjective impression, and insensitivity to subtle modifications.
To determine whether performance of inserting of pegs and tapping (i) correlates with each other (ii) differentiates between parkinsonian subjects and healthy controls and (iii) reflects severity of Parkinson's disease (PD).
In 157 previously untreated idiopathic parkinsonian patients and healthy controls, we measured (i) the total time taken to insert 25 pegs from a rack into a series of appropriate holes in a Purdue pegboard-like apparatus and (ii) the number of taps on a contact board with a contact pencil for a period of 32 seconds for assessment of fine motor skills.
Results of both tests correlated with each other, differed between parkinsonian subjects and controls and reflected scored severity of PD. Better correlation with intensity of PD was noted with the Purdue pegboard-like task.
Both tapping and inserting of pegs represent useful tools for objective evaluation of severity of PD. Peg insertion correlated better with disease severity. Both approaches may be useful in future clinical studies.
由于评分量表存在评分者间差异、主观印象以及对细微变化不敏感等缺点，许多研究者已开发出复杂的定量仪器程序用于客观评估帕金森病运动障碍。
确定插钉和轻敲测试（i）是否相互关联，（ii）能否区分帕金森病患者和健康对照，以及（iii）能否反映帕金森病（PD）的严重程度。
在157例未经治疗的特发性帕金森病患者和健康对照中，我们测量了（i）将25根钉子从架子插入类似普渡插板装置的一系列合适孔中所需的总时间，以及（ii）用接触铅笔在接触板上轻敲32秒的次数，以评估精细运动技能。
两项测试结果相互关联，帕金森病患者和对照之间存在差异，且反映了PD的评分严重程度。类似普渡插板的任务与PD强度的相关性更好。
轻敲和插钉都是客观评估PD严重程度的有用工具。插钉与疾病严重程度的相关性更好。这两种方法在未来的临床研究中可能都有用。
