Henry M C, Port C D, Kaufman D G
Cancer Res. 1975 Jan;35(1):207-17.
Three mixtures of benzo(alpha)(a)pyrene (BP) and ferric oxide with different physical properties were given intratracheally to Syrian golden hamsters for an examination of their neoplastic potential. Hamsters treated with a preparation containing large aggregates of BP and ferric oxide resulting from nucleation of BP on the particles showed an earlier onset and higher incidence of respiratory tract tumors than animals given a mixture containing smaller aggregates prepared by hand-grinding. The greatest number of tumors were present in the trachea and the predominant type was the squamous carcinoma. A third preparation in which the carcinogen was not attached to the ferric oxide showed a low tumor incidence similar to that present after intratracheal intubation of BP in gelatin without a carrier particle. For this model system of respiratory carcinogenesis, the physical attachment of BP and the carrier dust is necessary for a high tumor yield.
将三种具有不同物理性质的苯并(α)芘（BP）与三氧化二铁混合物经气管内注入叙利亚金仓鼠体内，以检测其致癌潜能。用含有大量BP聚集体和三氧化二铁的制剂（BP在颗粒上成核形成）处理的仓鼠，与给予手工研磨制备的含有较小聚集体混合物的动物相比，呼吸道肿瘤的发病时间更早，发病率更高。肿瘤数量最多的部位是气管，主要类型是鳞状细胞癌。第三种制剂中致癌物未附着在三氧化二铁上，其肿瘤发生率较低，类似于在无载体颗粒的明胶中经气管内注入BP后的发生率。对于这个呼吸道致癌模型系统，BP与载体粉尘的物理附着对于高肿瘤发生率是必要的。
