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调强放射治疗中作为剂量学质量保证的剂量监测单位验证计算

A monitor unit verification calculation in intensity modulated radiotherapy as a dosimetry quality assurance.

作者信息

Kung J H, Chen G T, Kuchnir F K

机构信息

Massachusetts General Hospital, Boston 02144, USA.

出版信息

Med Phys. 2000 Oct;27(10):2226-30. doi: 10.1118/1.1286553.

Abstract

In standard teletherapy, a treatment plan is generated with the aid of a treatment planning system, but it is common to perform an independent monitor unit verification calculation (MUVC). In exact analogy, we propose and demonstrate that a simple and accurate MUVC in intensity modulated radiotherapy (IMRT) is possible. We introduce the concept of modified Clarkson integration (MCI). In MCI, we exploit the rotational symmetry of scattering to simplify the dose calculation. For dose calculation along a central axis (CAX), we first replace the incident IMRT fluence by an azimuthally averaged fluence. Second, the Clarkson integration is carried over annular sectors instead of over pie sectors. We wrote a computer code, implementing the MCI technique, in order to perform a MUVC for IMRT purposes. We applied the code to IMRT plans generated by CORVUS. The input to the code consists of CORVUS plan data (e.g., DMLC files, jaw settings, MU for each IMRT field, depth to isocenter for each IMRT field), and the output is dose contribution by individual IMRTs field to the isocenter. The code uses measured beam data for Sc, Sp, TPR, (D/MU)ref and includes effects from multileaf collimator transmission, and radiation field offset. On a 266 MHz desktop computer, the code takes less than 15 to calculate a dose. The doses calculated with the MCI algorithm agreed within +/-3% with the doses calculated by CORVUS, which uses a 1 cm x 1 cm pencil beam in dose calculation. In the present version of MCI, skin contour variations and inhomogeneities were neglected.

摘要

在标准远距离治疗中,借助治疗计划系统生成治疗计划,但进行独立的监测单位验证计算(MUVC)是很常见的。与之完全类似,我们提出并证明在调强放射治疗(IMRT)中进行简单而准确的MUVC是可行的。我们引入了修正的克拉克森积分(MCI)的概念。在MCI中,我们利用散射的旋转对称性来简化剂量计算。对于沿中心轴(CAX)的剂量计算,我们首先用方位角平均注量代替入射的IMRT注量。其次,克拉克森积分是在环形扇区而不是扇形上进行的。我们编写了一个实现MCI技术的计算机代码,以便为IMRT目的进行MUVC。我们将该代码应用于由CORVUS生成的IMRT计划。该代码的输入包括CORVUS计划数据(例如,动态多叶准直器文件、射野挡块设置、每个IMRT射野的MU、每个IMRT射野到等中心的深度),输出是各个IMRT射野对等中心的剂量贡献。该代码使用测量的射束数据来计算Sc、Sp、组织体模比(TPR)、参考剂量率(D/MU),并包括多叶准直器传输和辐射野偏移的影响。在一台266 MHz的台式计算机上,该代码计算一次剂量所需时间不到15秒。用MCI算法计算的剂量与CORVUS计算的剂量在±3%的范围内一致,CORVUS在剂量计算中使用1 cm×1 cm的笔形束。在当前版本的MCI中,忽略了皮肤轮廓变化和不均匀性。

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