Drevets D A, Leenen P J
Department of Medicine, Oklahoma University Health Sciences Center and the Department of Veterans Affairs Medical Center (111/c), 921 NE 13th Street, Oklahoma City, OK 73104, USA.
Microbes Infect. 2000 Nov;2(13):1609-18. doi: 10.1016/s1286-4579(00)01317-4.
Microbes use numerous strategies to invade the central nervous system. Leukocyte-facilitated entry is one such mechanism whereby intracellular pathogens establish infection by taking advantage of leukocyte trafficking to the central nervous system. Key components of this process include peripheral infection and activation of leukocytes, activation of cerebral endothelial cells with or without concomitant infection, and trafficking of infected leukocytes to and through the blood-brain or blood-cerebrospinal fluid barrier.
微生物利用多种策略侵入中枢神经系统。白细胞介导的进入是其中一种机制，通过这种机制，细胞内病原体利用白细胞向中枢神经系统的转运来建立感染。这一过程的关键组成部分包括外周感染和白细胞激活、伴有或不伴有感染的脑内皮细胞激活，以及受感染白细胞向血脑屏障或血脑脊液屏障的转运并穿过该屏障。
