Ransohoff Richard M, Kivisäkk Pia, Kidd Grahame
The Mellen Center for Multiple Sclerosis Treatment and Research, Department of Neurology, 9500 Euclid Avenue, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
Nat Rev Immunol. 2003 Jul;3(7):569-81. doi: 10.1038/nri1130.
Leukocyte migration into and through tissues is fundamental to normal physiology, immunopathology and host defence. Leukocyte entry into the central nervous system (CNS) is restricted, in part, because of the blood-brain barrier (BBB). During the past decade, crucial components that are involved in the process of leukocyte migration have been identified and progress has been made in understanding the mechanisms of neuroinflammatory reactions. In this review, present knowledge of the trafficking determinants that guide the migration of leukocytes is superimposed onto the vascular and compartmental anatomy of the CNS. We discuss three distinct routes for leukocytes to enter the CNS and consider how different populations of leukocytes use trafficking signals to gain entry.
白细胞迁移进入组织并穿过组织，这对于正常生理功能、免疫病理学和宿主防御至关重要。白细胞进入中枢神经系统（CNS）受到限制，部分原因是血脑屏障（BBB）。在过去十年中，已经确定了参与白细胞迁移过程的关键成分，并且在理解神经炎症反应机制方面取得了进展。在这篇综述中，将目前关于指导白细胞迁移的转运决定因素的知识叠加到中枢神经系统的血管和分区解剖结构上。我们讨论了白细胞进入中枢神经系统的三种不同途径，并考虑了不同类型的白细胞如何利用转运信号进入中枢神经系统。
