Borrelli F, Izzo A A
Department of Experimental Pharmacology, University of Naples 'Federico II', via D. Montesano 49, 80131 Naples, Italy.
Phytother Res. 2000 Dec;14(8):581-91. doi: 10.1002/1099-1573(200012)14:8<581::aid-ptr776>3.0.co;2-s.
Phytogenic agents have traditionally been used by herbalists and indigenous healers for the prevention and treatment of peptic ulcer. This article reviews the anti-acid/anti-peptic, gastro-protective and/or anti-ulcer properties of the most commonly employed herbal medicines and their identified active constituents. Botanical compounds with anti-ulcer activity include flavonoids (i.e. quercetin, naringin, silymarin, anthocyanosides, sophoradin derivatives) saponins (i.e. from Panax japonicus and Kochia scoparia), tannins (i.e. from Linderae umbellatae), gums and mucilages (i.e. gum guar and myrrh). Among herbal drugs, liquorice, aloe gel and capsicum (chilli) have been used extensively and their clinical efficacy documented. Also, ethnomedical systems employ several plant extracts for the treatment of peptic ulcer. Despite progress in conventional chemistry and pharmacology in producing effective drugs, the plant kingdom might provide a useful source of new anti-ulcer compounds for development as pharmaceutical entities or, alternatively, as simple dietary adjuncts to existing therapies.
植物制剂传统上一直被草药医生和本土治疗师用于预防和治疗消化性溃疡。本文综述了最常用草药及其已确定的活性成分的抗酸/抗蛋白酶、胃保护和/或抗溃疡特性。具有抗溃疡活性的植物化合物包括黄酮类化合物（如槲皮素、柚皮苷、水飞蓟素、花色苷、槐定碱衍生物）、皂苷（如来自竹节参和地肤子）、单宁（如来自乌药）、树胶和黏液质（如瓜尔豆胶和没药）。在草药中，甘草、芦荟凝胶和辣椒已被广泛使用，其临床疗效也有记载。此外，民族医学体系使用多种植物提取物治疗消化性溃疡。尽管传统化学和药理学在生产有效药物方面取得了进展，但植物界可能为开发新的抗溃疡化合物提供有用的来源，这些化合物可作为药物实体，或者作为现有疗法的简单饮食辅助剂。
