Annibale B, Capurso G, Martino G, Grossi C, Delle Fave G
Department of Gastroenterology, Policlinico Umberto I, University La Sapienza, Viale del Policlinico 155, 00161 Rome, Italy.
Int J Antimicrob Agents. 2000 Dec;16(4):515-9. doi: 10.1016/s0924-8579(00)00288-0.
Iron deficiency anaemia (IDA) is the most common form of anaemia world-wide. IDA is the simple result of an imbalance between iron loss and absorption. Gastric function with hydrochloric and ascorbic acid is essential for iron absorption. Some strains of Helicobacter pylori are able to acquire iron, competing with the host. A large percentage of patients with atrophic body gastritis (ABG) develop IDA and 61% of them are H. pylori positive. Recent evidence suggests that H. pylori infection could cause IDA in the absence of peptic ulcer or other upper gastrointestinal (GI) tract bleeding lesions. Gastritis extending to the corpus and a high bacterial load are features of these patients. About 70% of IDA patients with ABG or H. pylori gastritis are premenopausal women. Both ABG and H. pylori gastritis should be considered when evaluating the GI tract of patients with iron deficiency anaemia.
缺铁性贫血（IDA）是全球最常见的贫血形式。IDA是铁丢失与吸收失衡的简单结果。具有盐酸和抗坏血酸的胃功能对于铁的吸收至关重要。某些幽门螺杆菌菌株能够获取铁，与宿主竞争。很大比例的萎缩性胃体炎（ABG）患者会发生IDA，其中61%为幽门螺杆菌阳性。最近的证据表明，在没有消化性溃疡或其他上消化道（GI）出血病变的情况下，幽门螺杆菌感染可能导致IDA。这些患者的特征是胃炎扩展至胃体且细菌载量高。约70%患有ABG或幽门螺杆菌胃炎的IDA患者为绝经前女性。在评估缺铁性贫血患者的胃肠道时，应同时考虑ABG和幽门螺杆菌胃炎。
