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RNA聚合酶：细菌RNA聚合酶与真核生物RNA聚合酶II之间的结构相似性

RNA polymerase: structural similarities between bacterial RNA polymerase and eukaryotic RNA polymerase II.

作者信息

Ebright R H

机构信息

Howard Hughes Medical Institute, Waksman Institute and Department of Chemistry Rutgers University, Piscataway, NJ 08854, USA.

出版信息

J Mol Biol. 2000 Dec 15;304(5):687-98. doi: 10.1006/jmbi.2000.4309.

DOI:10.1006/jmbi.2000.4309
PMID:11124018
Abstract

Bacterial RNA polymerase and eukaryotic RNA polymerase II exhibit striking structural similarities, including similarities in overall structure, relative positions of subunits, relative positions of functional determinants, and structures and folding topologies of subunits. These structural similarities are paralleled by similarities in mechanisms of interaction with DNA.

摘要

细菌RNA聚合酶与真核生物RNA聚合酶II在结构上有显著相似之处，包括整体结构、亚基的相对位置、功能决定因素的相对位置以及亚基的结构和折叠拓扑结构等方面的相似性。这些结构上的相似性与它们和DNA相互作用机制的相似性相对应。

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