Haft D H, Loftus B J, Richardson D L, Yang F, Eisen J A, Paulsen I T, White O
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
Nucleic Acids Res. 2001 Jan 1;29(1):41-3. doi: 10.1093/nar/29.1.41.
TIGRFAMs is a collection of protein families featuring curated multiple sequence alignments, hidden Markov models and associated information designed to support the automated functional identification of proteins by sequence homology. We introduce the term 'equivalog' to describe members of a set of homologous proteins that are conserved with respect to function since their last common ancestor. Related proteins are grouped into equivalog families where possible, and otherwise into protein families with other hierarchically defined homology types. TIGRFAMs currently contains over 800 protein families, available for searching or downloading at www.tigr.org/TIGRFAMs. Classification by equivalog family, where achievable, complements classification by orthology, superfamily, domain or motif. It provides the information best suited for automatic assignment of specific functions to proteins from large-scale genome sequencing projects.
TIGRFAMs是一个蛋白质家族集合,其特点是经过精心整理的多序列比对、隐马尔可夫模型及相关信息,旨在通过序列同源性支持蛋白质的自动功能鉴定。我们引入“对等同源物”一词来描述一组同源蛋白质中自其最近共同祖先以来在功能上保守的成员。相关蛋白质尽可能被归入对等同源物家族,否则归入具有其他层次定义同源类型的蛋白质家族。TIGRFAMs目前包含800多个蛋白质家族,可在www.tigr.org/TIGRFAMs上进行搜索或下载。在可行的情况下,按对等同源物家族进行分类可补充按直系同源、超家族、结构域或基序进行的分类。它提供了最适合从大规模基因组测序项目中自动为蛋白质指定特定功能的信息。