Coe C L, Crispen H R
Department of Psychology, University of Wisconsin, Madison 53706, USA.
Health Psychol. 2000 Nov;19(6):554-9.
The capacity of prenatal stress to disrupt the placental transfer of maternal antibody was evaluated in neonatal squirrel monkeys (Saimiri boliviensis peruviensis) gestated under different pregnancy conditions. Normal squirrel monkey offspring (n = 63) were compared with infants generated from pregnancies that involved either a single or 3 periods of disturbance (ns = 21 and 29, respectively). At parturition, levels of antibody (IgG) were determined in mothers and neonates. Only the chronic disturbance condition significantly altered antibody levels in the mothers, resulting in lower IgG. Antibody transfer to the fetus was also affected only by chronic disturbance. In this case the effect was bidirectional, influenced by the sex of the infant. Males were born with lower levels, whereas female infants actually had higher-than-normal IgG, despite lower titers in their mothers. Because virtually all IgG is derived from the prenatal transfer of maternal antibody, it indicates that the sex of the fetus differentially affected this placental process. The IgG receptor may have been up-regulated selectively on the placentas of female fetuses, compensating for reduced antibody in the disturbed mothers.
在不同妊娠条件下孕育的新生松鼠猴（秘鲁松鼠猴）中，评估了产前应激干扰母体抗体胎盘转运的能力。将正常松鼠猴后代（n = 63）与来自经历过单次或3次干扰期妊娠的婴儿进行比较（分别为n = 21和29）。分娩时，测定母亲和新生儿体内的抗体（IgG）水平。只有慢性干扰条件显著改变了母亲体内的抗体水平，导致IgG降低。抗体向胎儿的转运也仅受慢性干扰影响。在这种情况下，影响是双向的，受婴儿性别的影响。雄性出生时抗体水平较低，而雌性婴儿尽管母亲体内抗体滴度较低，但其IgG实际上高于正常水平。由于几乎所有IgG都源自母体抗体的产前转运，这表明胎儿性别对这种胎盘过程有不同影响。雌性胎儿的胎盘上IgG受体可能被选择性上调，以补偿受干扰母亲体内减少的抗体。
