Fleisher T A, Bleesing J J
Department of Laboratory Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
Pediatr Clin North Am. 2000 Dec;47(6):1197-209. doi: 10.1016/s0031-3955(05)70267-4.
The innate and the adaptive immune systems have evolved to provide a rapid and specific means for protecting hosts against the many microbes experienced over a lifetime. These two immune responses interact cooperatively to enhance the host defense. Defects in either of these two pathways can have devastating consequences, as evidenced [figure: see text] by primary immune deficiencies, many of which are discussed in this issue of the Pediatric Clinics of North America. The immune system has a central role in the pathogenesis of many disorders that involve an inflammatory response, including allergic and autoimmune diseases. New and more effective therapies for these many disorders will develop as the understanding of the immune system and its many secreted mediators continues to increase.
先天性免疫系统和适应性免疫系统不断进化，为宿主提供了一种快速且特异性的手段，以抵御一生中所接触到的众多微生物。这两种免疫反应协同相互作用，以增强宿主防御能力。这两条途径中任何一条出现缺陷都可能产生毁灭性后果，原发性免疫缺陷就证明了这一点[图：见正文]，本期《北美儿科学临床》中讨论了其中许多原发性免疫缺陷。免疫系统在许多涉及炎症反应的疾病（包括过敏性疾病和自身免疫性疾病）的发病机制中起着核心作用。随着对免疫系统及其众多分泌介质的认识不断加深，将会开发出针对这些众多疾病的更新、更有效的疗法。
