Phelps M E, Hoffman E J, Mullani N A, Ter-Pogossian M M
J Nucl Med. 1975 Mar;16(3):210-24.
A study was carried out to investigate the use of annihilation coincidence detection (ACD) in emmision transaxial reconstruction tomography. The ACD was evaluated in terms of spatial resolution and sensitivity with depth, detection efficiency, effect of pulse-height analysis on resolution and efficiency, correction for attenuation, and cold spot contrast. A prototype positron emission transaxial tomograph (PETT) consisting of a hexagonal array of 24 Nal (Tl) detectors employing ACD was constructed. A fast Fourier transform algorithm was employed to generate the reconstructed image. Computer simulations and phantom and animal studies were carried out to demonstrate that this approach yields tomographic radionuclide images that have high resolution and contrast (hot and cold spot) and that are independent of activity above and below the plane examined. The ACD yields a quantitative nuclear medicine imaging device with high detection efficiency. Comparisons are presented between the ACD and the scintillation camera and scanner. Discussion of the possible applications of the PETT in nuclear medicine is included.
开展了一项研究，以调查湮没符合探测（ACD）在发射型断层重建体层摄影术中的应用。从空间分辨率和深度灵敏度、探测效率、脉冲高度分析对分辨率和效率的影响、衰减校正以及冷区对比度等方面对ACD进行了评估。构建了一台由24个采用ACD的碘化钠（铊）探测器组成的六边形阵列的原型正电子发射断层扫描仪（PETT）。采用快速傅里叶变换算法生成重建图像。进行了计算机模拟、体模和动物研究，以证明这种方法可产生具有高分辨率和对比度（热区和冷区）且与所检查平面上方和下方的活度无关的断层放射性核素图像。ACD产生了一种具有高探测效率的定量核医学成像设备。给出了ACD与闪烁照相机和扫描仪之间的比较。还包括了对PETT在核医学中可能应用的讨论。
