Aggarwal N, Sawhney H, Vasishta K, Dhiman R K, Chawla Y
Department of Obstetrics and Gynecology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Int J Gynaecol Obstet. 2001 Jan;72(1):1-7. doi: 10.1016/s0020-7292(00)00263-0.
To study the outcome of pregnancy in women with non-cirrhotic portal hypertension (NCPH).
A retrospective analysis of 50 pregnancies in 27 women with NCPH was carried out. Pregnancy outcome was compared in extra hepatic portal vein obstruction (EHPVO) and non-cirrhotic portal fibrosis (NCPF).
The mean maternal age was 24.60+/-2.857 years, and the disease was diagnosed during pregnancy in 15 (55.6%) patients. Variceal bleeding occurred in 17/50 (34%) pregnancies and the majority (88.2%) of them responded to endoscopic sclerotherapy. Incidence of variceal bleeding during pregnancy was lower in pregnancies where the disease was diagnosed prior to pregnancy (8.6%), and it was 43.5% in EHPVO and 25.9% in NCPF. The mean birth weight of the neonates was 2668.4+/-427.42 g, and the incidence of abortion, prematurity, small for gestational age babies and perinatal death was 20, 17.5, 12.5 and 20%, respectively. Variceal bleeding during pregnancy was associated with a higher incidence of abortion (29.4%) and perinatal death (33.3%).
Variceal bleeding is the most common complication in pregnancies with NCPH. Pregnancies can be allowed and managed successfully in patients with NCPH.
研究非肝硬化门静脉高压症（NCPH）女性的妊娠结局。
对27例NCPH女性的50次妊娠进行回顾性分析。比较肝外门静脉阻塞（EHPVO）和非肝硬化门静脉纤维化（NCPF）的妊娠结局。
产妇平均年龄为24.60±2.857岁，15例（55.6%）患者在孕期被诊断出该病。17/50（34%）次妊娠发生静脉曲张出血，其中大多数（88.2%）对内镜硬化治疗有反应。妊娠前被诊断出该病的妊娠中，孕期静脉曲张出血的发生率较低（8.6%），EHPVO中为43.5%，NCPF中为25.9%。新生儿平均出生体重为2668.4±427.42 g，流产、早产、小于胎龄儿和围产儿死亡的发生率分别为20%、17.5%、12.5%和20%。孕期静脉曲张出血与较高的流产发生率（29.4%）和围产儿死亡发生率（3%.3%）相关。
静脉曲张出血是NCPH妊娠中最常见的并发症。NCPH患者可以妊娠并成功管理。
