Hetherington H P, Spencer D D, Vaughan J T, Pan J W
Medical Department, Brookhaven National Laboratory, Upton, New York, USA.
Magn Reson Med. 2001 Jan;45(1):46-52. doi: 10.1002/1522-2594(200101)45:1<46::aid-mrm1008>3.0.co;2-n.
This report describes the implementation and application of a multicompartment analysis of (31)P spectroscopic imaging data to determine the tissue-specific heterogeneities in metabolite content in the human brain and surrounding tissue. Using this information and a multicompartment regression analysis the phosphocreatine and ATP content of "pure" cerebral gray and white matter, the cerebellum, and skeletal muscle was determined in a group of 10 healthy volunteers. The data were converted to mM units using previously reported values for the T(1)s of phosphocreatine and ATP at 4 T, the water content of human brain, and an external reference for absolute quantification. The phosphocreatine concentration in cerebral gray and white matter, the cerebellum, and skeletal muscle was 3.53 +/- 0.33, 3.33 +/- 0.37, 3.75 +/- 0.66, and 25.8 +/- 2.3 mM, respectively. The ATP concentration in cerebral gray and white matter, the cerebellum, and skeletal muscle was 2.19 +/- 0.33, 3.41 +/- 0.33, 1.75 +/- 0.58, and 8.5 +/- 1.9 mM, respectively. Magn Reson Med 45:46-52, 2001.
本报告描述了对（31）P光谱成像数据进行多室分析的实施和应用，以确定人脑及周围组织中代谢物含量的组织特异性异质性。利用这些信息并通过多室回归分析，测定了10名健康志愿者组中“纯”脑灰质、白质、小脑和骨骼肌的磷酸肌酸和ATP含量。使用先前报道的4T时磷酸肌酸和ATP的T(1)值、人脑的含水量以及用于绝对定量的外部参考，将数据转换为mM单位。脑灰质、白质、小脑和骨骼肌中的磷酸肌酸浓度分别为3.53±0.33、3.33±0.37、3.75±0.66和25.8±2.3 mM。脑灰质、白质、小脑和骨骼肌中的ATP浓度分别为2.19±0.33、3.41±0.33、1.75±0.58和8.5±1.9 mM。《磁共振医学》45:46 - 52，2001年。
