Barker P B, Butterworth E J, Boska M D, Nelson J, Welch K M
Department of Neurology, Henry Ford Hospital, Detroit, Michigan, USA.
Magn Reson Med. 1999 Feb;41(2):400-6. doi: 10.1002/(sici)1522-2594(199902)41:2<400::aid-mrm26>3.0.co;2-e.
Multislice, two-dimensional phosphorus 31 spectroscopic imaging (SI) of human brain was performed in 15 normal volunteers on a 3-Tesla magnetic resonance system. Images of free magnesium concentrations and pH as well as phosphoesters, inorganic phosphate, phosphocreatine, and adenosine triphosphate (ATP), were calculated from the SI data. By using the equations of Golding and Golding (Magn. Reson. Med. 1995;33: 467-474), average [Mg2+] for all brain regions studied was 0.42+/-0.05 mM, whereas average brain pH was found to be 7.07+/-0.03, with no significant regional variations. Phosphorus metabolite concentrations (relative to ATP, assumed to be 3.0 mM/kg wet weight)were 5.39+/-1.88, 1.30+/-0.39, 5.97+/-3.17, and 4.33+/-1.45 mM/kg wet weight for phosphomonoesters, inorganic phosphate, phosphodiesters, and phosphocreatine (PCr), respectively. These values are in good general agreement with those reported previously. Typical signal-to-noise ratios of 15:1 were obtained for PCr in spectra from nominal 31.5 cc voxel sizes with a 34-min scan time. Limits on spatial resolution and the likely error of the magnesium and pH values are discussed.
在15名正常志愿者身上，使用3特斯拉磁共振系统对人脑进行了多层二维磷31光谱成像（SI）。根据SI数据计算出游离镁浓度、pH值以及磷酸酯、无机磷酸盐、磷酸肌酸和三磷酸腺苷（ATP）的图像。利用戈尔丁和戈尔丁的公式（《磁共振医学》1995年；33:46-474），研究的所有脑区的平均[Mg2+]为0.42±0.05 mM，而平均脑pH值为7.07±0.03，无明显区域差异。磷代谢物浓度（相对于ATP，假设为3.0 mM/kg湿重）分别为磷酸单酯5.39±1.88、无机磷酸盐1.30±0.39、磷酸二酯5.97±3.17和磷酸肌酸（PCr）4.33±1.45 mM/kg湿重。这些值与先前报道的值总体上非常一致。在标称31.5 cc体素大小、扫描时间为34分钟的光谱中，PCr的典型信噪比为15:1。讨论了空间分辨率的限制以及镁和pH值的可能误差。
