Schönburg M, Urbanek P, Erhardt G, Taborski U, Plechinger H, Hein S, Roth M, Klövekorn W P
Kerckhoff-Klinik GmbH Benekestr, 2-8 61231 Bad Nauhelm Germany.
J Extra Corpor Technol. 2000 Sep;32(3):165-9.
Microemboli passing to the cerebral circulation during cardiopulmonary bypass can contribute to postoperative neurologic dysfunction. Many studies conclude that air microbubbles predominantly are responsible for this problem. A dynamic bubble trap (DBT) was developed to diminish the number of microbubbles in the arterial line of extracorporeal circulation. The DBT is able to substantially reduce the number of air microbubbles, as shown in two patients undergoing coronary artery bypass grafting, where a high number of microbubbles was assessed. Although a 40-micron arterial filter was used, many bubbles larger than 40 microns occurred in the arterial line. The DBT reduced the number of large microbubbles from 2,267 to 67 in patient 1 and from 897 to 61 in patient 2.
在心肺转流期间进入脑循环的微栓子可导致术后神经功能障碍。许多研究得出结论,空气微泡是造成这一问题的主要原因。一种动态气泡捕捉器(DBT)被开发出来以减少体外循环动脉管路中的微泡数量。如在两名接受冠状动脉旁路移植术的患者中所显示的,DBT能够显著减少空气微泡的数量,在这两名患者中检测到大量微泡。尽管使用了一个40微米的动脉滤器,但动脉管路中仍出现了许多大于40微米的气泡。在患者1中,DBT将大气泡数量从2267个减少至67个,在患者2中从897个减少至61个。