Fontana R S
Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.
Cancer. 2000 Dec 1;89(11 Suppl):2352-5. doi: 10.1002/1097-0142(20001201)89:11+<2352::aid-cncr7>3.3.co;2-x.
The Mayo Lung Project (MLP) was a randomized, controlled, clinical trial designed to determine whether intensive radiologic and cytologic screening for lung carcinoma could reduce lung carcinoma mortality significantly.
Half the MLP population was encouraged (and reminded) to undergo free chest X-rays and free sputum cytology tests every 4 months for 6 years, whereas the other half of the population was advised to undergo the 2 tests yearly.
Lung carcinoma incidence rate, resectability, and survivorship were greater in the intensively screened group compared with the control group, but there was no significant difference in the lung carcinoma mortality rate between the two groups.
The intensive screening program cannot be recommended as a public health measure because it did not appear to result in decreased lung carcinoma mortality, even though it did yield an increased rate of incidence of apparently indolent tumors.
梅奥肺癌项目（MLP）是一项随机对照临床试验，旨在确定针对肺癌的强化放射学和细胞学筛查是否能显著降低肺癌死亡率。
MLP人群的一半被鼓励（并得到提醒）每4个月接受一次免费胸部X光检查和免费痰细胞学检查，持续6年，而另一半人群则被建议每年进行这两项检查。
与对照组相比，强化筛查组的肺癌发病率、可切除性和生存率更高，但两组之间的肺癌死亡率没有显著差异。
强化筛查项目不能作为一项公共卫生措施被推荐，因为它似乎并未导致肺癌死亡率下降，尽管它确实使明显惰性肿瘤的发病率有所增加。
