使用新型体外血小板功能分析仪评估新生儿的原发性止血功能。
Evaluation of primary hemostasis in neonates with a new in vitro platelet function analyzer.
作者信息
Israels S J, Cheang T, McMillan-Ward E M, Cheang M
机构信息
Department of of Pediatrics and Community Health Sciences and the Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba, Canada.
出版信息
J Pediatr. 2001 Jan;138(1):116-9. doi: 10.1067/mpd.2001.109794.
With the use of the PFA-100 platelet function analyzer to evaluate primary hemostasis in whole blood, measured as closure time (CT), neonates had shorter CTs than members of an adult control group. Multivariate analysis of measures that contribute to primary hemostasis showed that higher hematocrits and increased ristocetin cofactor activity were the best correlates for CTs of cord blood. These 2 factors may also enhance primary hemostasis in vivo and compensate for the impaired platelet function of the newborn.
使用PFA - 100血小板功能分析仪评估全血中的初级止血功能，以闭合时间（CT）作为衡量指标，新生儿的CT时间比成人对照组成员更短。对影响初级止血功能的各项指标进行多变量分析表明，较高的血细胞比容和增加的瑞斯托霉素辅因子活性与脐血的CT时间关联最为紧密。这两个因素也可能在体内增强初级止血功能，并弥补新生儿受损的血小板功能。
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