Timbrell J A
King's College London, London, United Kingdom.
Arh Hig Rada Toksikol. 2000 Sep;51(3):295-303.
Urinary creatine has been shown to markedly increase in rats following testicular damage caused by toxicants as diverse as cadmium, 2-methoxyethanol, 1,3-dinitrobenzene, and 2,3,5,6-tetramethylphenylene diamine. More recent findings have shown that urinary creatine is raised in mice exposed to 2-methoxyacetic acid. The most recent studies have revealed that urinary creatine and creatine in interstitial fluid in the testis are raised as early as four hours after dosing with 2-methoxyethanol. Using the testicular toxicants 2-methoxyethanol and cadmium, the authors compared urinary creatine with other markers of testicular damage, such as histopathological assessment of testis by light microscopy, testis weight and lactate dehydrogenase C4 isoenzyme, and testosterone. Urinary creatine was found to be the most sensitive indicator of testicular damage detected by histopathology after both 2-methoxyethanol and cadmium exposure. It is therefore a potentially very useful non-invasive biomarker of male reproductive dysfunction caused by chemicals.
已表明，在大鼠受到镉、2-甲氧基乙醇、1,3-二硝基苯和2,3,5,6-四甲基苯二胺等多种毒物导致的睾丸损伤后，尿肌酸会显著增加。最近的研究结果显示，暴露于2-甲氧基乙酸的小鼠尿肌酸升高。最新研究表明，在用2-甲氧基乙醇给药后仅4小时，睾丸间质液中的尿肌酸和肌酸就会升高。作者使用睾丸毒物2-甲氧基乙醇和镉，将尿肌酸与睾丸损伤的其他标志物进行了比较，如通过光学显微镜对睾丸进行组织病理学评估、睾丸重量、乳酸脱氢酶C4同工酶以及睾酮。结果发现，在暴露于2-甲氧基乙醇和镉之后，尿肌酸是通过组织病理学检测到的睾丸损伤最敏感的指标。因此，它是一种潜在的非常有用的、用于检测由化学物质引起的男性生殖功能障碍的非侵入性生物标志物。
