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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Nahas K, le Net J L, Provost J P, Tomaszewski K E

Laboratoires Pfizer, Centre de Recherche, Amboise, France.

Hum Exp Toxicol. 1993 Mar;12(2):173-6. doi: 10.1177/096032719301200214.

This study assessed urinary creatine excretion as a marker for testicular atrophy. 2. Male rats received a single i.p. dose of 2-methoxyethanol at 0, 250 or 750 mg kg-1 and were sacrificed 2 d later. Urinary creatine and creatinine excretion were measured on days 0, 1 and 2. 3. Decreased testicular weights and histopathological assessment revealed dose-related testicular damage. 4. On day 1, at both doses of 2-methoxyethanol, urinary creatine levels increased and creatinine levels decreased, resulting in a dose-related increase in the creatine/creatinine ratio. On day 2, the creatine/creatinine ratio was elevated relative to controls, but was less marked than on day 1. 5. The study confirmed that creatine excretion is a potential marker for acute testicular damage.

本研究评估了尿肌酸排泄量作为睾丸萎缩标志物的情况。2. 雄性大鼠腹腔注射一次剂量为0、250或750毫克/千克的2-甲氧基乙醇，2天后处死。在第0、1和2天测量尿肌酸和肌酐排泄量。3. 睾丸重量减轻和组织病理学评估显示存在剂量相关的睾丸损伤。4. 在第1天，两种剂量的2-甲氧基乙醇均使尿肌酸水平升高，肌酐水平降低，导致肌酸/肌酐比值呈剂量相关增加。在第2天，肌酸/肌酐比值相对于对照组升高，但不如第1天明显。5. 该研究证实肌酸排泄是急性睾丸损伤的一个潜在标志物。

Nahas K, le Net J L, Provost J P, Tomaszewski K E

Laboratoires Pfizer, Centre de Recherche, Amboise, France.

Hum Exp Toxicol. 1993 Mar;12(2):173-6. doi: 10.1177/096032719301200214.

This study assessed urinary creatine excretion as a marker for testicular atrophy. 2. Male rats received a single i.p. dose of 2-methoxyethanol at 0, 250 or 750 mg kg-1 and were sacrificed 2 d later. Urinary creatine and creatinine excretion were measured on days 0, 1 and 2. 3. Decreased testicular weights and histopathological assessment revealed dose-related testicular damage. 4. On day 1, at both doses of 2-methoxyethanol, urinary creatine levels increased and creatinine levels decreased, resulting in a dose-related increase in the creatine/creatinine ratio. On day 2, the creatine/creatinine ratio was elevated relative to controls, but was less marked than on day 1. 5. The study confirmed that creatine excretion is a potential marker for acute testicular damage.

本研究评估了尿肌酸排泄量作为睾丸萎缩标志物的情况。2. 雄性大鼠腹腔注射一次剂量为0、250或750毫克/千克的2-甲氧基乙醇，2天后处死。在第0、1和2天测量尿肌酸和肌酐排泄量。3. 睾丸重量减轻和组织病理学评估显示存在剂量相关的睾丸损伤。4. 在第1天，两种剂量的2-甲氧基乙醇均使尿肌酸水平升高，肌酐水平降低，导致肌酸/肌酐比值呈剂量相关增加。在第2天，肌酸/肌酐比值相对于对照组升高，但不如第1天明显。5. 该研究证实肌酸排泄是急性睾丸损伤的一个潜在标志物。