Butterworth M, Creasy D, Timbrell J A
Toxicology Department, School of Pharmacy, London, UK.
Arch Toxicol. 1995;69(3):209-11. doi: 10.1007/s002040050160.
We have previously shown that a number of testicular toxicants administered acutely to rats raise urinary creatine. The aim of this study was to determine if this creatinuria was maintained during subchronic testicular damage. Repeated exposure of rats to 2-methoxyethanol for 10 days administered in the drinking water caused significant testicular damage at the highest dose. The urinary creatine:creatine ratio was significantly increased in the animals receiving the highest dose (220 mg/kg per day) and also those receiving doses of 87 mg/kg per day. Increases in the ratio seen after the lowest dose (43 mg/kg per day) were significant in some cases, but showed more variability. Relative testicular weight was only significantly reduced after the highest dose. Increases in body weight over the time of exposure were only significantly lower after the highest dose of 2-methoxyethanol. The results indicate that urinary creatine may be a useful biomarker for chronic testicular damage.
我们之前已经表明，给大鼠急性施用多种睾丸毒物会使尿肌酸升高。本研究的目的是确定在亚慢性睾丸损伤期间这种肌酸尿是否持续存在。大鼠通过饮用水反复接触2-甲氧基乙醇10天，在最高剂量下导致了显著的睾丸损伤。接受最高剂量（每天220毫克/千克）以及每天接受87毫克/千克剂量的动物，其尿肌酸与肌酐比值显著升高。最低剂量（每天43毫克/千克）后观察到的该比值升高在某些情况下具有显著性，但变异性更大。仅在最高剂量后，相对睾丸重量才显著降低。在接触2-甲氧基乙醇的时间段内，仅在最高剂量后体重增加才显著较低。结果表明，尿肌酸可能是慢性睾丸损伤的一种有用生物标志物。
