Rawcliffe L, Creasy D, Timbrell J A
Toxicology Unit, School of Pharmacy, London.
Reprod Toxicol. 1989;3(4):269-74. doi: 10.1016/0890-6238(89)90021-x.
A single dose of 500 mg/kg of 2-methoxyethanol given to male rats caused testicular damage, detected by histopathology, a significant reduction in relative testis weight, and a significant rise in urinary creatine, maximal at 48 h after dosing. Further studies showed that the reduction in relative testis weight and creatine excretion were dose related. Conversely, urinary creatinine showed a dose-related decrease at 24 h after dosing. In female rats dosed with 500 mg/kg of 2-methoxyethanol, there was no increase in urinary creatine or decrease in creatinine. These data suggest that urinary creatine may be a useful, noninvasive marker of testicular damage.
给雄性大鼠单次注射500毫克/千克的2-甲氧基乙醇会导致睾丸损伤，通过组织病理学检测发现，相对睾丸重量显著降低，尿肌酸显著升高，给药后48小时达到峰值。进一步研究表明，相对睾丸重量的降低和肌酸排泄与剂量相关。相反，给药后24小时尿肌酐呈剂量相关下降。给雌性大鼠注射500毫克/千克的2-甲氧基乙醇后，尿肌酸没有增加，肌酐也没有减少。这些数据表明，尿肌酸可能是一种有用的、非侵入性的睾丸损伤标志物。
