Fidler I J
Department of Cancer Biology, Box 173, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030,USA.
J Natl Cancer Inst Monogr. 2001(28):10-4. doi: 10.1093/oxfordjournals.jncimonographs.a024251.
The progressive growth of neoplasms and the production of metastasis depend on the development of adequate vasculature, i.e., angiogenesis. The extent of angiogenesis is determined by the balance between positive- and negative-regulating molecules that are released by tumor and host cells in the microenvironment. The growth of many neoplasms is associated with the absence of the endogenous inhibitor of angiogenesis, interferon beta (IFN beta). A survey of multiple mouse and human tumors shows a lack of IFN beta associated with extensive angiogenesis. Therapy with IFN alpha or beta either by subcutaneous injection of the protein or by introduction of viral vectors that contain the IFN beta gene inhibit angiogenesis and, hence, progressive tumor growth.
肿瘤的渐进性生长和转移的产生依赖于充足脉管系统的形成，即血管生成。血管生成的程度由肿瘤和宿主细胞在微环境中释放的正调控分子和负调控分子之间的平衡所决定。许多肿瘤的生长与内源性血管生成抑制剂——干扰素β（IFNβ）的缺失有关。对多种小鼠和人类肿瘤的调查显示，缺乏IFNβ与广泛的血管生成有关。通过皮下注射蛋白或引入含有IFNβ基因的病毒载体进行α干扰素或β干扰素治疗，可抑制血管生成，从而抑制肿瘤的渐进性生长。
