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庆大霉素与依托铵联合使用对铜绿假单胞菌的活性

[Gentamycin activity in combination with etonium in relation to Pseudomonas aeruginosa].

作者信息

Tydel'skaia I L, Rozhavin M A, Sologub V V

出版信息

Antibiotiki. 1979 Jul;24(7):514-6.

PMID:111608
Abstract

Gentamicin is one of the most effective drugs for treatment of infections caused by Ps. aeruginosa. However, isolation of the strains resistant to the antibiotics was not infrequent. It was shown in the experiments with 40 cultures that the activity of gentamicin against Ps. aeruginosa increased approximately 20 times when it was used in combination with ethonium, a derivative of bis-quaternary ammonium compounds.

摘要

庆大霉素是治疗铜绿假单胞菌引起的感染最有效的药物之一。然而,分离出对抗生素耐药的菌株并不罕见。在对40种培养物进行的实验中表明,庆大霉素与双季铵化合物的衍生物乙磺铵联合使用时,其对铜绿假单胞菌的活性增加了约20倍。

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