Mitaka T
Department of Pathology, Cancer Research Institute, Sapporo Medical University School of Medicine, Chuo-Ku, S-1, W-17, Sapporo, 060-8556, Japan.
Biochem Biophys Res Commun. 2001 Feb 16;281(1):1-5. doi: 10.1006/bbrc.2001.4270.
Hematopoiesis and the hepatic environment are known to have a close relationship at the time of hepatic development and systemic diseases. Recently, transplanted cells isolated from bone marrow of rodents and humans have been shown to differentiate into oval cells, which are considered to be hepatic stem cells, and hepatocytes in the liver. Then, purified hematopoietic stem cells were shown to have the ability to replace original liver cells in mice with hereditary tyrosinemia. In this review the interactions between hepatic stem cells are summarized and a hypothesis of hepatic differentiation will be proposed.
造血作用与肝脏环境在肝脏发育及全身性疾病时期有着密切关系。最近，从啮齿动物和人类骨髓中分离出的移植细胞已被证明可分化为卵圆形细胞（被认为是肝干细胞）以及肝脏中的肝细胞。随后，纯化的造血干细胞被证明有能力替代患有遗传性酪氨酸血症小鼠的原始肝细胞。在这篇综述中，将总结肝干细胞之间的相互作用，并提出肝分化的假说。
