Alfredson H, Ljung B O, Thorsen K, Lorentzon R
Department of Surgical and Perioperative Science, Umeå University, Sweden.
Acta Orthop Scand. 2000 Oct;71(5):475-9. doi: 10.1080/000164700317381162.
We used the microdialysis technique to study concentrations of substances in the extensor carpi radialis brevis (ECRB) tendon in patients with tennis elbow. In 4 patients (mean age 41 years, 3 men) with a long duration of localized pain at the ECRB muscle origin, and in 4 controls (mean age 36 years, 2 men) with no history of elbow pain, a standard microdialysis catheter was inserted into the ECRB tendon under local anesthesia. The local concentrations of the neurotransmitter glutamate and prostaglandin E2 (PGE2) were recorded under resting conditions. Samplings were done every 15 minutes during a 2-hour period. We found higher mean concentrations of glutamate in ECRB tendons from patients with tennis elbow than in tendons from controls (215 vs. 69 micromoL/L, p < 0.001). There were no significant differences in the mean concentrations of PGE2 (74 vs. 86 pg/mL). In conclusion, in situ microdialysis can be used to study certain metabolic events in the ECRB tendon of the elbow. Our findings indicate involvement of the excitatory neurotransmitter glutamate, but no biochemical signs of inflammation (normal PGE2 levels) in ECRB tendons from patients with tennis elbow.
我们采用微透析技术研究网球肘患者桡侧腕短伸肌（ECRB）肌腱中物质的浓度。在4例（平均年龄41岁，3例男性）ECRB肌起点处存在长期局部疼痛的患者以及4例（平均年龄36岁，2例男性）无肘部疼痛病史的对照者中，在局部麻醉下将标准微透析导管插入ECRB肌腱。记录静息状态下神经递质谷氨酸和前列腺素E2（PGE2）的局部浓度。在2小时内每15分钟进行一次采样。我们发现，网球肘患者ECRB肌腱中谷氨酸的平均浓度高于对照组肌腱（215对69微摩尔/升，p<0.001）。PGE2的平均浓度无显著差异（74对86皮克/毫升）。总之，原位微透析可用于研究肘部ECRB肌腱中的某些代谢事件。我们的研究结果表明，兴奋性神经递质谷氨酸参与其中，但网球肘患者ECRB肌腱中无炎症的生化迹象（PGE2水平正常）。
