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两性霉素B胶体分散体治疗免疫功能正常成年患者地中海内脏利什曼病的疗效

Efficacy of amphotericin B colloidal dispersion in the treatment of Mediterranean visceral leishmaniasis in immunocompetent adult patients.

作者信息

Gaeta G B, Maisto A, Di Caprio D, Scalone A, Pasquale G, Felaco F M, Galante D, Gradoni L

机构信息

Dipartimento di Malattie Infettive, Seconda Università, Naples, Italy.

出版信息

Scand J Infect Dis. 2000;32(6):675-7. doi: 10.1080/003655400459612.

DOI:10.1080/003655400459612
PMID:11200380
Abstract

Twelve immunocompetent adults with Mediterranean visceral leishmaniasis (VL) were treated with amphotericin B colloidal dispersion (ABCD; 2 mg/kg/d for 7 d). All patients showed rapid clinical response without significant adverse events. Two weeks after therapy they were parasitologically cured and no relapses occurred during 6 months. ABCD is a valid alternative in the management of Mediterranean VL in adult patients.

摘要

12名患有地中海内脏利什曼病(VL)的免疫功能正常的成年人接受了两性霉素B胶体分散液(ABCD;2mg/kg/天,共7天)治疗。所有患者均表现出快速的临床反应,且无明显不良事件。治疗两周后,他们在寄生虫学上得到治愈,并且在6个月内未出现复发。ABCD是成年患者地中海VL治疗中的一种有效替代方案。

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