Bakir T, Can G, Erkul S, Siviloglu C
Ondokuz Mayis University, Faculty of Medicine, Department of Gastroenterology, Samsun, Turkey.
Eur J Cancer Prev. 2000 Dec;9(6):401-8. doi: 10.1097/00008469-200012000-00005.
A case-control study in the population of the Eastern Black Sea region of Turkey was conducted to learn the incidence of stomach cancer in the siblings of patients with gastric carcinoma. Among 1240 patients with gastric carcinoma, 168 had sibling(s) with a history of stomach cancer versus 19 cases in the control group matched according to age and gender (OR 10.07, P < 0.0001). The frequency of a history of stomach cancers and cancer of other organs in first- to third-degree relatives was 60.7% and 38.0%, respectively, of 168 sibling cases with gastric carcinoma (P < 0.0001). Fifty-two point three per cent of sibling cases having a history of cancer in other organs in their relatives also reported stomach cancer in the same-degree relatives. The number of stomach cancers in the first- to third-degree relatives of sibling cases was higher than the number of other organ cancers in the same-degree relatives (P < 0.01). Familial clustering of stomach cancer was reported in 12.5% of sibling cases. The study of stomach cancer history in the siblings suggests: the presence of a genetic susceptibility, high risk of the disease occurrence in the siblings of patients, higher predisposition to gastric than to other organ cancers in the relatives, and not infrequent familial clustering.
在土耳其黑海东部地区人群中开展了一项病例对照研究，以了解胃癌患者的兄弟姐妹中胃癌的发病率。在1240例胃癌患者中，168例有患胃癌的兄弟姐妹，而在按年龄和性别匹配的对照组中这一数字为19例（比值比10.07，P<0.0001）。在168例有胃癌的兄弟姐妹病例中，一级至三级亲属中有胃癌病史和其他器官癌症病史的频率分别为60.7%和38.0%（P<0.0001）。亲属中有其他器官癌症病史的兄弟姐妹病例中，52.3%在同等级亲属中也有胃癌。兄弟姐妹病例的一级至三级亲属中胃癌的数量高于同等级亲属中其他器官癌症的数量（P<0.01）。12.5%的兄弟姐妹病例报告有胃癌家族聚集性。对兄弟姐妹胃癌病史的研究表明：存在遗传易感性、患者的兄弟姐妹中疾病发生风险高、亲属中患胃癌的易感性高于其他器官癌症、且家族聚集性并不罕见。
