人胶质瘤中的热休克蛋白表达
Heat shock protein expression in human gliomas.
作者信息
Strik H M, Weller M, Frank B, Hermisson M, Deininger M H, Dichgans J, Meyermann R
机构信息
Institute of Brain Research, Medical School, University of Tübingen, Calwer Str. 3, D-72076 Tübingen, Germany.
出版信息
Anticancer Res. 2000 Nov-Dec;20(6B):4457-62.
BACKGROUND
Heat shock proteins (HSP) are cytoprotective, antiapoptotic proteins which may predict clinical prognosis in various types of cancer. Here, we asked whether the differential response to radiochemotherapy and different overall prognosis for astrocytic and oligodendroglial tumours can be accounted for by differences in HSP expression.
MATERIAL AND METHODS
We examined aB-crystallin, HSP27, HSP70, HSC70 (HSP73) and HSP90 expression in 44 human gliomas (5 anaplastic and 5 low-grade astrocytomas, 5 anaplastic and 5 low-grade oligodendrogliomas and 24 glioblastomas) by immunohistochemistry.
RESULTS
HSP were expressed in the tumour parenchyma of all high-grade and most low-grade gliomas, including oligodendrogliomas. Endothelial cells were more often positive for HSC70 and HSP90, but more often negative for HSP27, in glioblastomas than in the other tumours. HSP were also observed in macrophages/microglial cells, but not in a tumour-specific pattern.
CONCLUSION
Different patterns of HSP expression seem not to account for the differential response of these tumours to adjuvant cytotoxic therapy.
背景
热休克蛋白（HSP）是具有细胞保护作用的抗凋亡蛋白，可能预测各类癌症的临床预后。在此，我们探讨星形细胞瘤和少突胶质细胞瘤对放化疗的不同反应及不同的总体预后是否可由HSP表达差异来解释。
材料与方法
我们采用免疫组化法检测了44例人类胶质瘤（5例间变性和5例低级别星形细胞瘤、5例间变性和5例低级别少突胶质细胞瘤以及24例胶质母细胞瘤）中αB-晶状体蛋白、HSP27、HSP70、HSC70（HSP73）和HSP90的表达。
结果
HSP在所有高级别和大多数低级别胶质瘤（包括少突胶质细胞瘤）的肿瘤实质中均有表达。在胶质母细胞瘤中，内皮细胞HSC70和HSP90阳性更为常见，但HSP27阳性则比其他肿瘤更为少见。在巨噬细胞/小胶质细胞中也观察到HSP，但无肿瘤特异性模式。
结论
不同的HSP表达模式似乎无法解释这些肿瘤对辅助细胞毒性治疗的不同反应。
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